Melanoma Cell Adhesion Molecule (CD 146) in Endometrial Physiology and Disorder

The human endometrium, the innermost lining of the uterus, is the anatomic prerequisite for pregnancy. It is the only dynamic tissue that undergoes more than 400 cycles of regeneration throughout the reproductive life of women. Key to this function are endometrial stem cells as well as cell adhesion molecules. Melanoma cell adhesion molecule (MCAM/CD146/MUC18) is a membrane glycoprotein of the mucin family and a key cell adhesion protein, highly expressed by endometrial cells. CD146 is a significant molecule pivotal in endometrial physiology, assisting tissue regeneration and angiogenesis. Endometrium also acts as a culprit in causing several endometrial dysfunctions, such as endometriosis, endometrial hyperplasia, and endometrial carcinoma, due to interrupted molecular and functional mechanisms. Though most of the endometrial dysfunctions arise as a result of endocrine disturbance, it has a major pathological role associated with angiogenesis. It has already been proven that CD146 is a potential marker for the diagnosis of angiogenic dysfunctions and malignancy, including endometrial cancer. However, its mechanistic role in causing the pathology is a mystery. This chapter explores the role of CD146 in normal and pathological endometrial conditions and the therapeutic implications of CD146. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others Abbreviations - AA4: - Anti-CD146 monoclonal antibody clone - AA98: - Anti-CD146 monoclonal antibody clone - AKT-mTOR: - Protein kinase B (Akt)/mammalian target of rapamycin (mTOR) - ALCAM: - Activated leukocyte cell adhesion molecule - a-SMA: - α-smooth muscle actin - CAMs: - Cell adhesion molecules - C-CAM: - Cell-CAM - CCL20: - Chemokine (C-C motif) ligand 20 - CD146: - Cluster of differentiation 146 - CSF: - Cerebrospinal fluid - EC: - Endometrial carcinoma - ECM: - Extracellular matrix - EH: - Endometrial hyperplasia - EMT: - Epithelial-mesenchymal transition - ERK: - Extracellular signal–regulated kinase - ETTs: - Epithelioid trophoblastic tumors - FSH: - Follicle-stimulating hormone - Gab1: - Growth-factor receptor–bound protein 2–associated protein - Gai 1/3: - Gelectin 3 - HUVECs: - Human umbilical vein endothelial cells - ICAM-1: - Intercellular adhesion molecule-1 - IgSF: - Immunoglobulin superfamily - IL10: - Interleukin 10 - IUD: - Intrauterine device - JAK1: - Janus kinase 1 - kDa: - Kilodalton - Ki-67: - Antigen Kiel 67 - lg CD146: - CD146 long isoform - LH: - Luteinizing hormone - M2J-1: - Neutralizing monoclonal antibody - mAb: - Monoclonal antibody - MCAM: - Melanoma cell adhesion molecule - MDA-MB-231: - Human breast cancer cell line - MET-CAM: - Metastasis cell adhesion molecule - MSC: - Mesenchymal stem cells - N-CAM: - Neural cell adhesion molecule - NFKB: - Nuclear factor kappa B - NG2: - Neuron glia antigen-2 - NR4A3: - Nuclear receptor subfamily 4 group A member 3 - P53: - Tumor protein 53 - PCOS: - Polycystic ovarian syndrome - PDGFR β: - Platelet-derived growth factor receptor beta - PSD95: - Drosophila disc large tumor suppressor - PSD95: - Postsynaptic density protein - sCD146: - Soluble CD146 - sh CD146: - CD146 short isoform - STAT3: - Signal transducer and activator of transcription 3 - TNBC: - Triple-negative breast cancer - VEGF: - Vascular endothelial growth factor - WHO: - World Health Organization - Wnt/beta: - Wingless-related integration site beta - Zo-1: - Zonula occludens-1 protein

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Springer, Cham. https://doi.org/10.1007/5584_2024_826 Download citation DOI: https://doi.org/10.1007/5584_2024_826 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-031-83688-6 Online ISBN: 978-3-031-83689-3 eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)