Investigating the rate of different ovarian response in in vitro fertilization cycles based on estrogen receptor beta +1730 polymorphism: A cross-sectional study.

Parsa E, Mehdi Hoseini S, Mahdieh Namayandeh S, Akhavansales Z, Hasan Sheikhha M
International journal of reproductive biomedicine · 2020 · doi:10.18502/ijrm.v13i7.7368 · PMID:32803202 · PMC7385910
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This cross-sectional study of 91 infertile women found no association between the ESR2 gene +1730 G/A polymorphism and ovarian response parameters or pregnancy rates during in vitro fertilization cycles.

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This cross-sectional study investigated whether the ESR2 gene +1730 G/A polymorphism influences ovarian response and pregnancy outcomes in 91 infertile women undergoing in vitro fertilization. The researchers excluded patients with male factor infertility and endometriosis to isolate genetic effects on ovulation induction, analyzing variables such as follicle count, oocyte yield, and embryo quality. Results indicated no statistically significant association between the polymorphism genotypes and any of these reproductive parameters or clinical pregnancy rates. Relevance to endometriosis: endometriosis was explicitly excluded from the study population, so this paper does not provide data on the condition but cites prior literature linking the polymorphism to increased endometriosis risk.

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Abstract

BackgroundThe response to ovarian stimulation is different among women referring for assisted reproductive techniques. This difference could be due to different genotypes in genes related to reproduction such as estrogen receptor beta (ERβ or ESR2) gene.ObjectiveIn the present study, we explored the rate of ESR2 gene polymorphism in infertile women undergoing IVF treatment with different ovarian response to ovulation induction.Materials and methodsA cross-sectional study was performed among 91 infertile women. The relationship between genotype distribution of the +1730 G/A polymorphism in the ESR2 gene (rs4986938) and the mean number of follicles and oocytes, their mean ratio, mean number of embryos, mean size of the follicles and pregnancy rates were measured. The ESR2 gene +1730 G/A polymorphism were identified by the amplification-refractory mutation system-polymerase chain reaction.ResultsGenotypes GG, GA, and AA of the ESR2 gene presented frequencies of 27.5%, 67%, and 5.5%, respectively, in the infertile women. The results of the study showed that the mean number of follicles and oocytes, their mean ratio, mean number of embryos, mean size of the follicles, and pregnancy rates are not related to different genotypes.ConclusionAccording to the endocrine and paracrine factors which are involved in the ovulation induction and maturation of oocytes, more studies with higher number of participants are required to confirm the results of the present study; in addition, further studies are required to find out other gene polymorphisms affecting estrogen receptor efficacy in the infertile women.
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According to the relatively low percentage of treatment responses to IVF cycles, more attention is needed to focus on pharmacogenetics and patient's individual response. This study investigated the importance of a gene involved in human reproduction. Based on statistical analysis, the number of follicles is related to the outcome of pregnancy while age and estrogen are the effective factors on follicle numbers. For further study the role of the ESR2 gene +1730 G/A polymorphism in infertility, the prevalence of the polymorphism is necessary to be evaluated in normal populations. If various differences in infertile women are identified by further investigations and determination of polymorphisms in different genes, proper planning can be done to choose effective agents in the treatment of each individual according to the genetic background. This will eventually lead to an increase in pregnancy rates in infertile patients, preventing excessive use of drugs and avoiding to give false hope to infertile couples.

Coi Statement

There was no conflict of interest in this study.

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