Новые подходы к диагностике генитального эндометриоза

The paper discusses diagnostic approaches for genital endometriosis, focusing on morphologic and immunohistochemical assessment of nerve fiber expression in endometrial tissue. It summarizes evidence that the density of nerve fibers in the functional layer of the endometrium in women with endometriosis is significantly higher than in healthy women, and that measuring nerve fibers in endometrial biopsies yields accuracy and sensitivity approaching those of laparoscopy, with the caveat that laparoscopy still cannot evaluate depth of invasion and some studies note high nerve fiber concentration even in patients with pain but without morphologic confirmation. The authors also review how nerve fibers and related biomarkers are linked to chronic pelvic pain and how this concept may enable a less invasive diagnostic method, potentially using endometrial biopsy rather than surgical verification. This paper is centrally about endometriosis — specifically, it proposes nerve-fiber expression in endometrial biopsies as a less invasive but reliable diagnostic route for genital endometriosis.

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