BAT STRIKES: PAST, PRESENT, AND FUTURE

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Everolimus suppressed endometriotic foci in a rat model by promoting apoptosis without negatively affecting ovarian reserve, supporting its potential as a new therapeutic agent for endometriosis.

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This paper reviews data from the Bird Strike Committee-USA/Canada Joint Annual Meeting to analyze bat species involved in aircraft collisions. It highlights that while most bats are small and insectivorous, they can cause significant damage, particularly when encountered in swarms or by new aircraft operations. The study emphasizes the critical role of the Smithsonian Institution’s National Museum of Natural History in identifying fragmented specimens, noting that the Brazilian free-tailed bat is the most frequently identified species in U.S. Air Force strikes. These identifications provide valuable insights into bat flight patterns and timing, which may also inform wind energy resource development. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Introduction Mammalian target of rapamycin is a pathway to block apoptosis. Recent studies showed that the activity of mammalian target of rapamycin pathway increases in endometriotic lesions. Aim of the present study was to study the effect of everolimus agent, a rapamycin analog, in an experimental endometriosis model. Materials and Methods Endometriosis established by the autotransplantation of uterine tissue in the peritoneal cavity was confirmed in 24 rats. The animals were then randomly divided into three groups to receive either everolimus (1.5 mg/kg/day, p. o.), anastrozole (0.004 mg/day, p. o.), or normal saline (0.1 mL, i. p.) for 14 days. Endometriotic foci were excised, stained with hematoxylin and eosin, and endometriosis was scored semiquantitatively. In addition, immunohistochemical examination were performed using primary antibodies of vascular endothelial growth factor, CD117, and Bax. Results Both anastrozole and everolimus lowered endometriosis scores. Significant decreases in ovarian follicles were observed following anastrozole treatment but not everolimus treatment. Conclusion Through its apoptosis-promoting effect, everolimus suppressed endometriotic foci without negatively affecting ovarian reserve. These findings support the hypothesis that everolimus merits further study on the way to developing a new endometriosis drug.
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Bird Strike Committee Proceedings Bird Strike Committee-USA/Canada Joint Annual Meeting: 8th (2006) Accessibility Remediation If you are unable to use this item in its current form due to accessibility barriers, you may request remediation through our remediation request form. Date of this Version August 2006 Document Type Article Abstract All but a few North American bats are insectivorous and weigh less than 35 g, but this diverse group of mammals also contains species with wingspans up to 2 meters and weighing a kg or more. Even small-bodied bats can cause considerable damage when encountered in swarms. When aircraft head into new territory and encounter strikes, the ability to identify the species of bat struck is paramount to preventing future strikes. Identifications of bats from fragmentary evidence are made by comparing samples recovered from aircraft with specimens housed in the Smithsonian Institution’s National Museum of Natural History. This collection, worldwide in scope, is the largest collection of mammal specimens in existence. The species of bat most frequently identified in U.S. Air Force aircraft strikes is the Brazilian free-tailed bat, Tadarida brasiliensis (38%). Tree bats, which include the red bat, Lasiurus borealis (19%), Seminole bat, L. seminolus (7%), and hoary bat, L. cinereus (13%), along with strikes identified only to the genus level, collectively comprise 44% of identified bat strikes. The information obtained from these identifications has already greatly enhanced our understanding of when and where bats are flying. The data associated with these aircraft strikes in respect to date, time, location, and altitude of flight may also provide important insights for other projects, such as the development of wind energy resources.

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