Local Side Effects of Subcutaneous and Intramuscular Urinary Gonadotropins for Ovarian Stimulation in In Vitro Fertilization: A Prospective, Randomized Study

Lawrence Engmann, Adel Shaker, Emma White, Jinan Bekir, Howard S. Jacobs, Seang Lin Tan
In: Fertility and Sterility · 1998 · vol. 69(5) , pp. 836–840 · doi:10.1016/s0015-0282(98)00043-0 · PMID:9591489 · W2075040420
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This prospective, randomized study compared local side effects of subcutaneous versus intramuscular administration of urinary gonadotropins during ovarian stimulation for IVF.

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Abstract

ObjectiveTo compare the incidence and severity of local side effects of urinary-derived gonadotropins administered s.c. and i.m..DesignProspective randomized study of women undergoing IVF treatment.SettingTertiary referral center for assisted reproduction.Patient(s)A total of 71 patients were randomized to receive gonadotropins by the s.c. (n = 41) or i.m. (n = 30) route.Intervention(s)One cycle of IVF with gonadotropins administered either s.c. or i.m. for ovarian stimulation.Main outcome measure(s)Incidence and severity of local side effects, such as redness, itching, swelling, pain, and bruising.Result(s)Pain was the most common side effect, with 55.3% and 70.1% of i.m. and s.c. injections, respectively, resulting in pain. There were no statistically significant differences in the incidence of itching or bruising after i.m. and s.c. injections. Although there was a higher incidence of redness and swelling in the s.c. group compared with the i.m. group, most cases were classified as mild.Conclusion(s)There was a significantly higher incidence of some local side effects after s.c. gonadotropin administration but most of these were mild and well tolerated by patients.

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