Bio-nanocomposite based highly sensitive and label-free electrochemical immunosensor for endometriosis diagnostics application

Thangapandi K, Thangapandi Kalyani, Arumugam Sangili, Amalesh Nanda, Nanda A, Prakash S, Sengodu Prakash, Ajeet Kaushik, Kumar Jana S, Saikat Kumar Jana
Bioelectrochemistry (Amsterdam, Netherlands) · 2021 · vol. 139 , pp. 107740 · doi:10.1016/j.bioelechem.2021.107740 · PMID:33524653 · W3118689635
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Researchers developed a bio-nanocomposite electrochemical immunosensor for label-free detection of endometriosis biomarkers.

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Abstract

In this research, for the first time, a bio-nanocomposites based highly sensitive and label-free electrochemical immunosensor is reported with the aim of endometriosis diagnostics application. Multiwalled carbon nanotube and magnetite nanoparticle (MWCNT-Fe3O4) was dispersed in chitosan (CS) to fabricate a bio-nanocomposite to immobilize very monoclonal specific antibody (via cross-linking using glutaraldehyde) for selective electrochemical immuno-sensing of carbohydrate antigen 19-9 (CA19-9), a potential biomarker for endometriosis diagnostics. Well-characterized Anti-AbsCA19-9/CS-MWCNT-Fe3O4 immune-electrode fabricated on glassy carbon electrode (GCE) successfully detect CA 19-9 and exhibited a high sensitivity as (2.55 µA pg-1 cm-1), a detection limit of 0.163 pg mL-1, detection range from 1.0 pg mL-1 to 100 ng mL-1. Our fabricated electrochemical AbsCA19-9/CS-MWCNT-Fe3O4 immunosensor performed CA19-9 sensing in physiological range and at a very level which suggest it application for early-stage diagnostics, diseases monitoring, and optimization of therapy. To claim the clinical application, our sensor was tested using real samples and sensing performance was validated using enzyme-linked immune-sorbent assay (ELISA). The results of the studies projected AbsCA19-9/CS-MWCNT-Fe3O4 electrochemical CA19-9 immunosensor as a potential and affordable alternate of conventional techniques like ELISA. We believe that our fabricated sensor can be the plane of a disease's management program due to affordable, rapid, label-free, and sensitive detection of a targeted biomarker.

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Condition tags

endometriosis

MeSH descriptors

Antigens, Tumor-Associated, Carbohydrate Biosensing Techniques Electrochemical Techniques Endometriosis Immunoassay Point-of-Care Testing Point-of-Care Testing Antigens, Tumor-Associated, Carbohydrate Antigens, Tumor-Associated, Carbohydrate Biosensing Techniques Biosensing Techniques Chitosan Chitosan Chitosan Electrochemical Techniques Electrochemical Techniques Electrodes Electrodes Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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