Inhibition of embryo development by some maternal sera

Shirley B; B Shirley; Wortham JW Jr; J W Wortham; Peoples D; D Peoples; S White; White S; M Condon-Mahony; Condon-Mahony M

doi:10.1007/BF01555446

Inhibition of embryo development by some maternal sera

Shirley B, B Shirley, Wortham JW Jr, J W Wortham, Peoples D, D Peoples, S White, White S, M Condon-Mahony, Condon-Mahony M

Journal of in vitro fertilization and embryo transfer : IVF · 1987 · doi:10.1007/BF01555446 · PMID:3598307

other OA: closed public-domain-us

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This study found that maternal serum ability to support mouse embryo development in vitro did not correlate with pregnancy success or specific infertility causes like endometriosis, indicating such inhibition does not necessarily prevent successful IVF.

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This study evaluated whether maternal sera collected from patients undergoing in vitro fertilization could support the development of mouse embryos in culture. The researchers tested serum samples across various infertility etiologies, including endometriosis, ureaplasma infection, pelvic adhesive disease, and bilateral tubal occlusion. They found significant variability in serum efficacy but no correlation between a sample's ability to support embryo growth and the donor’s eventual pregnancy success or specific cause of infertility. Relevance to endometriosis: listed as one indication for infertility among the causes examined, though the paper's main focus is on embryo culture media supplementation rather than endometriosis pathology.

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Abstract

Blood sera obtained from patients in an in vitro fertilization and embryo transfer program at the time of oocyte retrieval were tested for their capacities to support embryo development by using them as supplements for media in which mouse embryos were cultured. The sera varied greatly in their capacities to support development of mouse embryos but there was no correlation between the effectiveness of the sera in supporting mouse embryo development and the achievement of pregnancy by the donors of the sera. The capacities of the serum samples to support embryo development also failed to correlate with any of the causes of infertility examined (endometriosis, ureaplasma infection, pelvic adhesive disease, and bilateral tubal occlusion). It was concluded that failure of maternal sera to support embryo development does not necessarily reduce the likelihood that the donors of the sera can become pregnant by in vitro fertilization and embryo transfer procedures.

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Abstract

References

Shirley B, Wortham JWE Jr, Witmyer J, Condon-Mahony M, Fort G: Effects of human serum and plasma on development of mouse embryos in culture media. Fertil Steril 1985;43:129–134 Ham RG: An improved nutrient solution for diploid Chinese hamster and human cell lines. Exp Cell Res 1963;29:515–526 Condon-Mahony M, Wortham JWE Jr, Bundren JC, Witmyer J, Shirley B: Evaluation of human fetal cord sera, Ham's F-10 medium, and in vitro culture materials with a mouse in vivo fertilization system. Fertil Steril 1985;44:521–525 Toyoda Y, Chang MC: Fertilization of rat eggsin vitro by epididymal spermatozoa and the development of eggs following transfer. J Reprod Fertil 1974;36:9–22 Author information Authors and Affiliations Rights and permissions About this article Cite this article Shirley, B., Wortham, J.W.E., Peoples, D. et al. Inhibition of embryo development by some maternal sera. J Assist Reprod Genet 4, 93–97 (1987). https://doi.org/10.1007/BF01555446 Received: Accepted: Issue date: DOI: https://doi.org/10.1007/BF01555446

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Condition tags

endometriosisinfertility

MeSH descriptors

Culture Media Embryonic and Fetal Development Infertility, Female Animals Culture Media Culture Media Embryonic and Fetal Development Embryo Transfer Female Fertilization in Vitro Humans Infertility, Female Mice Mice, Inbred C57BL Mice, Inbred C57BL Mice, Inbred CBA Mice, Inbred CBA Organ Culture Techniques Organ Culture Techniques Pregnancy

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