{"paper_id":"61b04906-1b8d-40d2-8237-1f710e56b3cb","body_text":"Abstract\nBlood sera obtained from patients in an in vitro fertilization and embryo transfer program at the time of oocyte retrieval were tested for their capacities to support embryo development by using them as supplements for media in which mouse embryos were cultured. The sera varied greatly in their capacities to support development of mouse embryos but there was no correlation between the effectiveness of the sera in supporting mouse embryo development and the achievement of pregnancy by the donors of the sera. The capacities of the serum samples to support embryo development also failed to correlate with any of the causes of infertility examined (endometriosis, ureaplasma infection, pelvic adhesive disease, and bilateral tubal occlusion). It was concluded that failure of maternal sera to support embryo development does not necessarily reduce the likelihood that the donors of the sera can become pregnant by in vitro fertilization and embryo transfer procedures.\nSimilar content being viewed by others\nReferences\nShirley B, Wortham JWE Jr, Witmyer J, Condon-Mahony M, Fort G: Effects of human serum and plasma on development of mouse embryos in culture media. Fertil Steril 1985;43:129–134\nHam RG: An improved nutrient solution for diploid Chinese hamster and human cell lines. Exp Cell Res 1963;29:515–526\nCondon-Mahony M, Wortham JWE Jr, Bundren JC, Witmyer J, Shirley B: Evaluation of human fetal cord sera, Ham's F-10 medium, and in vitro culture materials with a mouse in vivo fertilization system. Fertil Steril 1985;44:521–525\nToyoda Y, Chang MC: Fertilization of rat eggsin vitro by epididymal spermatozoa and the development of eggs following transfer. J Reprod Fertil 1974;36:9–22\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nShirley, B., Wortham, J.W.E., Peoples, D. et al. Inhibition of embryo development by some maternal sera. J Assist Reprod Genet 4, 93–97 (1987). https://doi.org/10.1007/BF01555446\nReceived:\nAccepted:\nIssue date:\nDOI: https://doi.org/10.1007/BF01555446","source_license":"public-domain-us","license_restricted":false}