Clinical assessment of the condition of women of reproductive age with adenomyosis after experiencing COVID-19

In: Reports of Vinnytsia National Medical University · 2023 · vol. 27(1) , pp. 69–73 · doi:10.31393/reports-vnmedical-2023-27(1)-13 · W4366336650
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AI-generated summary by claude@2026-06, 2026-06-07

This study assessed 150 women of reproductive age post-COVID-19, finding that those with adenomyosis experienced a significantly more severe course of their condition, with increased general malaise and exacerbated extragenital and gynecological pathology.

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The study assessed the clinical condition of 150 women of reproductive age after COVID-19, including 120 with adenomyosis, using mathematical statistics and Student’s parametric test (p<0.05). The authors report that in the early post-COVID period adenomyosis had a significantly more severe clinical course, with increased frequency of complaints such as general malaise, headaches, lethargy, joint and muscle pain, and pelvic pain, and that worse overall condition was associated with higher adenomyosis severity (I–II vs III–IV). They also found increased reports of exacerbation of extragenital diseases, gynecological pathology including menstrual function and increased menstrual blood loss, pelvic pain syndrome, and inflammatory (infectious) etiology processes. The paper does not state key methodological limitations in the abstract beyond the observational clinical assessment and statistical approach, and it frames the findings as practically important for management algorithm development. This paper is centrally about adenomyosis — it evaluates changes in women’s clinical symptoms after COVID-19.

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Abstract

Annotation. The relevance of the gynecological disease adenomyosis (N80.0) is beyond doubt, as this pathology is a serious problem today both in medicine and in society. The aim is to study the clinical condition of women of reproductive age with adenomyosis after suffering COVID-19. 150 women of reproductive age were examined after suffering COVID-19 disease, 120 of them with adenomyosis. The results obtained were processed using the methods of mathematical statistics and using the MS Excel XP, Statistica 6.0 software package using Student's parametric test. At the same time, differences were considered statistically significant at p<0.05. A clinical assessment of the condition of women of reproductive age with adenomyosis after suffering COVID-19 confirmed a significantly more severe course of adenomyosis in the early post-COVID period. After undergoing COVID-19, the frequency of complaints of general malaise, headaches, lethargy, pain in the joints, muscles, and pelvis in women aggravated by adenomyosis significantly increased. The more severe the degree of the disease (I-II, III-IV), the worse was the general condition of the examined patients. The frequency of complaints about general malaise, exacerbation of extragenital diseases (cardiovascular system, gastrointestinal tract, hepatobiliary system, anemia, etc.), gynecological pathology, including disorders of menstrual function, volume of menstrual blood loss, pelvic pain syndrome, presence of processes of inflammatory (infectious) etiology increased significantly. Determining the clinical assessment of the condition of women of reproductive age with adenomyosis after suffering COVID-19 is of fundamental practical importance for determining the tactics of managing this cohort of patients with the aim of timely qualified prevention of possible complications. Prospects for further research are aimed at developing and implementing an algorithm for managing women of reproductive age with adenomyosis after suffering COVID-19.
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Clinical assessment of the condition of women of reproductive age with adenomyosis after experiencing COVID-19 DOI: https://doi.org/10.31393/reports-vnmedical-2023-27(1)-13Keywords: clinical condition, women of reproductive age, adenomyosis, Сovid-19.Abstract Annotation. The relevance of the gynecological disease adenomyosis (N80.0) is beyond doubt, as this pathology is a serious problem today both in medicine and in society. The aim is to study the clinical condition of women of reproductive age with adenomyosis after suffering COVID-19. 150 women of reproductive age were examined after suffering COVID-19 disease, 120 of them with adenomyosis. The results obtained were processed using the methods of mathematical statistics and using the MS Excel XP, Statistica 6.0 software package using Student's parametric test. At the same time, differences were considered statistically significant at p<0.05. A clinical assessment of the condition of women of reproductive age with adenomyosis after suffering COVID-19 confirmed a significantly more severe course of adenomyosis in the early post-COVID period. After undergoing COVID-19, the frequency of complaints of general malaise, headaches, lethargy, pain in the joints, muscles, and pelvis in women aggravated by adenomyosis significantly increased. The more severe the degree of the disease (I-II, III-IV), the worse was the general condition of the examined patients. The frequency of complaints about general malaise, exacerbation of extragenital diseases (cardiovascular system, gastrointestinal tract, hepatobiliary system, anemia, etc.), gynecological pathology, including disorders of menstrual function, volume of menstrual blood loss, pelvic pain syndrome, presence of processes of inflammatory (infectious) etiology increased significantly. Determining the clinical assessment of the condition of women of reproductive age with adenomyosis after suffering COVID-19 is of fundamental practical importance for determining the tactics of managing this cohort of patients with the aim of timely qualified prevention of possible complications. Prospects for further research are aimed at developing and implementing an algorithm for managing women of reproductive age with adenomyosis after suffering COVID-19. Downloads References Bakun, O. V., & Tkachuk, A. I. (2019). Вплив генітального ендометріозу та супутніх захворювань на безпліддя за даними ретроспективного аналізу історій хвороби [Influence of genital endometriosis and concomitant diseases on infertility under the data of the retrospective analysis of case histories]. Буковинський медичний вісник – Bukovinian Medical Herald, 4(92), 9-15. Bird, C. C., & Mc Elin, T. W. (1983). Adenomyosіs and other Benihn Duffuse Enlar gemento fthe Uterus. Philadelphia: Sciarra Gynecology and Obstetrics, 112(3-7), 1-13. Bruijn, A. M., Lohle, P. N., Huirne, J. A., de Vries, J., & Twisk, M. (2018). Uterine artery embolization versus hysterectomy in the treatment of symptomatic adenomyosis: protocol for the randomized OUESTA Trial. JMIR Res Protoc., 1, 7(3), e47. doi: 10.2196/resprot.8512 Del Turco, S., Vianello, A., Ragusa, R., Chiara, Caselli, Ch., & Basta G. (2020). COVID-19 and cardiovascular conseguences: Is the endothelial dysfunction the hardest challenge? Thromb Res., 196, 143-151. Doi.org/10.1016/j.thromres.2020.08.039 Goncharenko, G. Yu. (2019). Роль естрогенових і прогестеронових рецепторів у жінок з аденоміозом у постменопаузі [The role of estrogen and progesterone receptors in postmenopausal women with adenomyosis]. Вісник Вінницького національного медичного університету – Reports of the Vinnytsia National Medical University, 1(23), 148-152. DOI: 10/31393/reports–vnmedical –2019–23(1)–26 National Institute for Health and Care Excellence (NICE). (2020). COVID-19 rapid guideline: managing the long-term effects of COVID-19. London. htts://www.nice.org.uk/guidance/ng188 Pontis, A., D’Alterio, M.N., Pirarba, S., de Angelis, C., Tinelli, R., & Angioni, R. S. (2016). Adenomiosis: a systematic review of medical treatment. Gynecol Endocrinol., 32(9), 696-700. doi: 10.1080/09513590.2016.1197200 Potapov, V. O. (2021). Аденоміоз: проблемні питання лікування [Adenomyosis: problematic issues of treatment]. Акушерство Гінекологія Репродуктологія – Obstetrics Gynecology Reproduction, 2, 43. Pryputnevich, T. V., Gordeev, A. B., Lyubasovskaya, L. A., & Shabanova, N. E. (2020). Новый коронавирус SARS-COV-2 и беременность: обзор литературы [The new coronavirus SARS-COV-2 and pregnancy: a literature review]. Акушерство и гинекология – Obstetrics and gynecology, 5, 6-12. https://dx.doi.org/10.18565/aig.2020.5.6-12 Tatarchuk, T. F., Zakharenko, N. F., Regeda, S. I., & Kvasha, T. I. (2022). Алгоритми призначення менопаузальної гормональної терапії в різні періоди менопаузи [Algorithms for prescribing menopausal hormone therapy in different periods of menopause]. Репродуктивная эндокринология – Reproductive Endocrinology, 4(66), 68-70. DOI: http://dx.doi.org/10.18370/2309-4117.2022.66.68-70 Varga, Z., Flammer, A. J., Steiger, P., Haberecker, M., Andermatt, R. Zinkernagel, A. S., .... & Moch, H. (2020). Endothelial cell infection and endotheliitis in COVID-19. Lancet, 395(10234), 1417-1418. doi.org/10.1016/SO140-6736(20)30937-5

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