Phoenixin-14 effect on viability and THBS2 and CDH1 expression in 12Z endometriosis cell line

Karolina Kulińska
2024 · doi:10.34808/71qf-pr48 · W6890131671
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Phoenixin-14, at endometriosis-specific concentrations, downregulated THBS2 expression and bidirectionally affected 12Z cell viability, but not CDH1 expression.

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This study investigated the impact of Phoenixin-14, a neuropeptide with reduced levels in endometriosis patients, on the viability and gene expression of the 12Z endometrial epithelial cell line. The researchers exposed these cells to Phoenixin-14 concentrations observed in women with endometriosis and analyzed changes in THBS2 and CDH1 expression alongside cell survival rates. Results indicated that Phoenixin-14 initially decreased and subsequently increased cell viability while specifically downregulating THBS2, a protein associated with epithelial-to-mesenchymal transition, without altering CDH1 levels. This paper is centrally about endometriosis, focusing on the molecular mechanisms by which altered Phoenixin-14 levels may influence epithelial cell behavior and extracellular matrix interactions in endometriotic lesions.

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Description Phoenixin-14 is a neuropeptide produced by the paraventricular nuclei of the anterior hypothalamus that regulates reproductive system functions. Its level in patients with endometriosis is reduced and may be the cause of dysregulated HPG-axis. Our study tested endometriosis-specific concentrations of PNX-14 on endometrial epithelial cell line 12Z in vitro. We found that PNX downregulates THBS2 expression, the protein involved in the epithelial-to-mesenchymal transition, with no changes in CDH1 expression. PNX-14 at the level observed in women with endometriosis first decreases and, next, increases the viability of endometrial epithelial cells. There is a link between endometriosis-specific PNX-14 concentration and extracellular matrix proteins expression. Dataset file hexmd5(md5(part1)+md5(part2)+...)-{parts_count} where a single part of the file is 512 MB in size.Example script for calculation: https://github.com/antespi/s3md5 File details - License: - open in new tabCC 0Public Domain Dedication - Raw data: - Data contained in dataset was not processed. Details - Year of publication: - 2024 - Related location: - Poznań, województwo wielkopolskie, Polska (52° 24′ 24″ N, 16° 53′ 27″ E) - Verification date: - 2024-06-24 - Creation date: - 2023 - Dataset language: - English - Fields of science: - - medical biology (Medical and Health Sciences ) - health sciences (Medical and Health Sciences ) - DOI: - DOI ID 10.34808/71qf-pr48 open in new tab - Verified by: - No verification Keywords References - publication Potential Modulatory Role of Phoenixin-14 in Epithelial–Mesenchymal Transition of Endometriotic 12Z Cells Cite as Authors seen 184 times

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endometriosis

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