{"paper_id":"5ff65b98-a140-4475-a853-933eef28fd29","body_text":"Description\nPhoenixin-14 is a neuropeptide produced by the paraventricular nuclei of the anterior hypothalamus that regulates reproductive system functions. Its level in patients with endometriosis is reduced and may be the cause of dysregulated HPG-axis. Our study tested endometriosis-specific concentrations of PNX-14 on endometrial epithelial cell line 12Z in vitro. We found that PNX downregulates THBS2 expression, the protein involved in the epithelial-to-mesenchymal transition, with no changes in CDH1 expression. PNX-14 at the level observed in women with endometriosis first decreases and, next, increases the viability of endometrial epithelial cells. There is a link between endometriosis-specific PNX-14 concentration and extracellular matrix proteins expression.\nDataset file\nhexmd5(md5(part1)+md5(part2)+...)-{parts_count}\nwhere a single part of the file is 512 MB in size.Example script for calculation:\nhttps://github.com/antespi/s3md5\nFile details\n- License:\n-\nopen in new tabCC 0Public Domain Dedication\n- Raw data:\n- Data contained in dataset was not processed.\nDetails\n- Year of publication:\n- 2024\n- Related location:\n- Poznań, województwo wielkopolskie, Polska (52° 24′ 24″ N, 16° 53′ 27″ E)\n- Verification date:\n- 2024-06-24\n- Creation date:\n- 2023\n- Dataset language:\n- English\n- Fields of science:\n-\n- medical biology (Medical and Health Sciences )\n- health sciences (Medical and Health Sciences )\n- DOI:\n- DOI ID 10.34808/71qf-pr48 open in new tab\n- Verified by:\n- No verification\nKeywords\nReferences\n- publication Potential Modulatory Role of Phoenixin-14 in Epithelial–Mesenchymal Transition of Endometriotic 12Z Cells\nCite as\nAuthors\nseen 184 times","source_license":"CC0","license_restricted":false}