Hormone Replacement Therapy and Risks of Various Cancers in Postmenopausal Women with De Novo or a History of Endometriosis

Hee Joong Lee, Banghyun Lee, Hangseok Choi, Minkyung Lee, Kyungjin Lee, Tae Kyoung Lee, Sung Ook Hwang, Yong Beom Kim
Cancers · 2024 · vol. 16(4) · doi:10.3390/cancers16040809 · PMID:38398200 · PMC10886569
other OA: gold CC-BY-4.0
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Abstract

This study examined the impact of hormone replacement therapy (HRT) on the occurrence of various cancers in postmenopausal women with de novo or a history of endometriosis. In the datasets for ten cancers (cervical, uterine, ovarian, breast, colon, gastric, liver, lung, pancreatic, and thyroid), women who received HRT (the HRT group) and those who did not (the control group) were selected by a 1:1 matching with those who met the study criteria. In the dataset for each cancer, the incidence of each cancer was very low (0.2% to 1.5% in the HRT group and 0.2% to 1.3% in the control group). The duration of HRT was 1.3 ± 2.1 years. After adjusting for co-variables, HRT was a significant risk factor for uterine cancer (p < 0.05). However, the risk of liver cancer decreased significantly with duration of HRT (p < 0.05). Moreover, combined estrogen and progesterone decreased the risks of liver and thyroid cancers significantly (p < 0.05), and estrogen alone decreased the risks of breast and lung cancers significantly (p < 0.05). Tibolone was not associated with the risk of any of the cancers assessed. These results can help guide the use of HRT in women with de novo or a history of endometriosis.

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endometriosis

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chemicals 51
hormone estrogen progesterone estrogen tibolone hormone estrogen estrogen estrogen estrogen tibolone estrogen progesterone estrogen progesterone tibolone hormone estrogen progesterone estrogen tibolone estrogen progesterone estrogen tibolone estrogen estrogen tibolone estrogen progesterone estrogen tibolone progestin estrogen tibolone estrogen estrogen tibolone estrogen tibolone estrogen estrogen estrogen estrogen estrogen estrogen estrogen estrogen estrogen progesterone estrogen

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