Uterus and endometrium: Flow cytometric DNA analysis in endometriotic tissue compared to normal uterine endometrium
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Flow cytometric DNA analysis of endometriosis and normal endometrium revealed primarily diploid DNA patterns with no convincing differences in S-phase fraction between the tissues.
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Abstract
Endometriotic tissue sometimes shows an invasive pattern, but the growth regulation of the tissue is insufficiently characterized. In a research programme on factors regulating endometriotic growth, the DNA ploidy status and S-phase fraction (SPF) were studied. Fresh-frozen endome triotic tissue from 14 women and endometrium from 11 of them were studied using flow cytometry. A clear diploid pattern was seen in most cases of endometriotic (8/14) and endometrial (8/11) samples. In the remaining cases the G0/G1peak was broad or skewed, which might indicate a near-diploid cell population. To clarify this, a second group was studied, consisting of 29 formalin-flxed endometriotic samples from 22 women and endometrium from five of them. All these samples were diploid, with one having a broad G peak. No convincing difference in SPF between endometrium and endometriotic tissue was found, as the calculations had to be handled with caution because of debris in many samples. Although the study of fresh-frozen samples gave some indications of differences in DNA ploidy status, flow cytometric DNA analysis of formalin fixed samples of endometriosis showed a diploid DNA pattern in all samples. In conclusion, DNA flow cytometry did not show a convincing aneuploid DNA pattern in endometriotic tissue.
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Cites (4)
- Human Endometrium and Endometriotic Tissue Obtained Simultaneously 1984
- Epidermal growth factor in human endometrium: proliferative effects in culture and immunocytochemical localization in normal and endometriotic tissues 1991
- Epidermal growth factor receptor expression in normal endometrium and endometriosis: an immunohistochemical study 1992
- Endocrine dependency of endometriosis: an ultrastructural study 1984
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