The immninent dawn of SPRMs in obstetrics and gynecology

Nathalie Chabbert-Buffet, Chabbert-Buffet N, Nathalie Chabbert‐Buffet, Axelle Pintiaux, Pintiaux A, Bouchard P, Philippe Bouchard
Molecular and cellular endocrinology · 2012 · vol. 358(2) , pp. 232–243 · doi:10.1016/j.mce.2012.02.021 · PMID:22415029 · W2000777228
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This review discusses the potential applications of selective progesterone receptor modulators (SPRMs) in obstetrics and gynecology, highlighting their mechanisms and therapeutic promise.

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Abstract

Selective progesterone receptor modulators (SPRMs) have been developed since the late 70s when mifepristone was first described. They act through nuclear progesterone receptors and can have agonist or mixed agonist antagonist actions depending on the cell and tissue. Mifepristone has unique major antagonist properties allowing its use for pregnancy termination. Ulipristal acetate has been marketed in 2009 for emergency contraception and has been recently approved for preoperative myoma treatment. Further perspectives for SPRMs use include long term estrogen free contraception, endometriosis treatment. However long term applications will be possible only after confirmation of endometrial safety.

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MeSH descriptors

Gynecology Hormone Antagonists Obstetrics Contraception Female Hormone Antagonists Hormone Antagonists Hormone Antagonists Humans Mifepristone Mifepristone Mifepristone Mifepristone Receptors, Progesterone Receptors, Progesterone Receptors, Progesterone

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