Modulation of female rats steroidogenesis in the application of balneotherapy in an experimental model of chronic endometritis

A. E. Chernova, О. В. Ремнева, И.П. Бобров, О. Н. Мазко, А.В. Лепилов, Yu. A. Shadeeva
In: Fundamental and Clinical Medicine · 2024 · vol. 9(4) , pp. 20–28 · doi:10.23946/2500-0764-2024-9-4-20-28 · W4406237142
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Abstract

Aim. Assess steroidogenesis modulation efficacy of balneotherapy in experimental chronic endometritis model. Materials and Мethods. The experimental endometritis was induced in laboratory Wistar line rats (n = 30) inoculated with intra-uterine self-fecal suspension. Starting with the 3nd day of the experiment, all animals have recieved wide-spectrum antibiotic within 7 days; from day 41– experimental group animals (n=10) applying 10 procedures of radon therapy one a day lasting 15 minutes. Comparison group animals (n = 10) received radon therapy and 10 procedures of peloid therapy mud according to a radon therapy regimen. Control group (n = 10) received no treatment. The venous estradiol and progesterone levels were analyzed by enzyme-linked immunosorbent assay. Histological verification was conducted by endometrium histology study. Results . In control group it was found maximal endometrial diffuse infiltrate 180.7 ± 9.0 immunocompetent cells. During balneotherapy treatment density of inflammatory infiltrate was lower in experimental group 125.4 ± 8.1 (by 30.7% vs. control group; p = 0.002), whereas in comparison group density of inflammatory infiltration was minimal (reduced by 88.7 % compared to control group; p < 0.001) and reached 20.5 ± 1.8 cells. Most pronounced rise in serum progesterone level had resulted in experimental group during radon therapy compared to control group (p = 0.008), meanwhile in comparison group featured with no significant change in estradiol level compared to control group (р = 0.95). Conclusion. During radon therapy is accompanied by significantly increased serum progesterone and decreased estradiol level along with chronic endometritis markers regression which can be used in future prospective studies for confirming its effectiveness in patients with reproductive system patology including diseases accompanied by hyperestrogenism.

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