THE ANTIOXIDATIVE DEFENCE IN WOMEN WITH EXTERNAL ENDOMETRIOSIS

L.V. Adamyan, О. Н. Логинова, М. М. Сонова, K. N. Arslanyan
In: Акушерство, гинекология и репродукция, Vol 8, Iss 3, Pp 18-21 (2016) · 2016 · W2770804747
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This study found that women with external endometriosis exhibited increased ceruloplasmin, decreased transferrin, and elevated NO-binding capacity in their blood, indicating oxidative stress.

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The study investigated antioxidative defense markers in 60 women with external endometriosis using spectroscopy, measuring active ceruloplasmin (CP) and transferin (TF) concentrations and the blood protein NO-capacity. Women with external endometriosis had higher active CP, lower TF, and an increased CP/TF ratio, alongside a significant increase in NO-capacity compared with both relatives and a control group of healthy women. The paper attributes these findings to an imbalance in the oxidant–antioxidant system and development of oxidative stress, but it does not report further methodological details such as how relatives were defined or any adjustment for confounders. This paper is centrally about endometriosis — it focuses on altered antioxidative defense and oxidative stress biomarkers in women with external endometriosis.

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Abstract

We studied the indexes of antioxidative defence – the concentration of active form of enzymes ceruloplasmin (CP) and transferin (TF) and NO-capacity of the protein of blood in 60 women with external endometriosis by method spectroscopy. The concentration of active form of ceruloplasmin was increased and the concentration of transferin was decreased in women with external endometriosis; the index CP/TF was increased. The NO-connective capacity of theblood was significant increased in this group of women comparing with their relatives and the control (healthy women) group. These changes are the result of the breach of balance in the system oxidant\antioxidant and the development of oxidative stress in this group of women.
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Акушерство, гинекология и репродукция (Jun 2016) THE ANTIOXIDATIVE DEFENCE IN WOMEN WITH EXTERNAL ENDOMETRIOSIS Abstract We studied the indexes of antioxidative defence – the concentration of active form of enzymes ceruloplasmin (CP) and transferin (TF) and NO-capacity of the protein of blood in 60 women with external endometriosis by method spectroscopy. The concentration of active form of ceruloplasmin was increased and the concentration of transferin was decreased in women with external endometriosis; the index CP/TF was increased. The NO-connective capacity of theblood was significant increased in this group of women comparing with their relatives and the control (healthy women) group. These changes are the result of the breach of balance in the system oxidant\antioxidant and the development of oxidative stress in this group of women.

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