MicroRNA-191-5p exerts a tumor suppressive role in renal cell carcinoma.

Print ISSN: 1792-0981 Online ISSN: 1792-1015 International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease. International Journal of Oncology is an international journal devoted to oncology research and cancer treatment. Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery. Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine. Oncology Letters is an international journal devoted to Experimental and Clinical Oncology. Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology. International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis. Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology. Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition. Publishes open-access research on using epigenetics to advance understanding and treatment of human disease. An International Open Access Journal Devoted to General Medicine. Article - Authors: - Pages: 1686-1693|Published online on: November 28, 2017https://doi.org/10.3892/etm.2017.5581 - Expand metrics + Renal cell carcinoma (RCC) is a common tumor of the urinary system. Previously, miR‑191‑5p has been reported to be associated with various types of cancer; however, its specific functions in RCC have not been investigated to date. In the present study, the expression of miR‑191‑5p in the 786‑O and ACHN cell lines was detected in vitro by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). The results of RT‑qPCR revealed that miR‑191‑5p was significantly downregulated in the two cell lines compared with the 293T cell line. miR‑191‑5p was also significantly downregulated in RCC tissue compared with paired normal tissue. In addition, the effects of miR‑191‑5p on cell proliferation, migration, invasion and apoptosis were examined by CCK‑8, MTT, wound scratch, Transwell and flow cytometry assays. Downregulation of miR‑191‑5p was observed to promote cell proliferation, migration and invasion, as well as to repress the cell apoptosis of 786‑O and ACHN cells. Therefore, the current study suggests that miR‑191‑5p functions as a tumor suppressor in RCC. Further studies are required to uncover the underlying signaling pathway of miR‑191‑5p and its potential role as a biomarker for early detection and prognosis prediction, and as a therapeutic target of RCC. Copy and paste a formatted citation Spandidos Publications style Chen P, Pan X, Zhao L, Jin L, Lin C, Quan J, He T, Zhou L, Wu X, Wang Y, Wang Y, et al: MicroRNA‑191‑5p exerts a tumor suppressive role in renal cell carcinoma. Exp Ther Med 15: 1686-1693, 2018. APA Chen, P., Pan, X., Zhao, L., Jin, L., Lin, C., Quan, J. ... Lai, Y. (2018). MicroRNA‑191‑5p exerts a tumor suppressive role in renal cell carcinoma. Experimental and Therapeutic Medicine, 15, 1686-1693. https://doi.org/10.3892/etm.2017.5581 MLA Chen, P., Pan, X., Zhao, L., Jin, L., Lin, C., Quan, J., He, T., Zhou, L., Wu, X., Wang, Y., Ni, L., Yang, S., Lai, Y."MicroRNA‑191‑5p exerts a tumor suppressive role in renal cell carcinoma". Experimental and Therapeutic Medicine 15.2 (2018): 1686-1693. Chicago Chen, P., Pan, X., Zhao, L., Jin, L., Lin, C., Quan, J., He, T., Zhou, L., Wu, X., Wang, Y., Ni, L., Yang, S., Lai, Y."MicroRNA‑191‑5p exerts a tumor suppressive role in renal cell carcinoma". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1686-1693. https://doi.org/10.3892/etm.2017.5581