Diagnostic value of serum CA125 level and endometrial aromatase detection to endometriosis

Objective To explore the value of serum CA125 level and endometrial aromatase detection to the diagnosis of endometriosis.Methods Forty patients with endometriosis diagnosed by laparoscopy or laparotomy(endometriosis group) and 20 patients receiving laparoscopy due to pelvic inflammatory disease(control group) were detected the serum CA125 level before operation.The expression of aromatase protein was detected with immunohistochemistry.The results were compared between two groups.Results Serum CA125 level was higher in endometriosis group than that in control group(P0.05),and was higher in Ⅲ to Ⅳ stage of endometriosis than that in Ⅰ to Ⅱstage(P0.05).Aromatase expression of eutopic endometrium was higher in endometriosis group than that in control group(P0.05),and showed no significant difference between Ⅲ to Ⅳ stage and Ⅰ to Ⅱ stages(P0.05).As the cut-off of serum CA125≥35 u/mL,the sensitivity for endometriosis was 55.0% and the specificity was 80.0%.The diagnostic sensitivity of endometrial aromatase expression detected with immunohistochemistry was 92.5% and the specificity was 90.0%.The sensitivity of the combined methods for endometriosis was 95.0%,and the specificity was 70.5%.Conclusion The combination of serum CA125 and endometrial aromatase assay may enhance the early diagnosis rate and diagnostic accuracy of endometriosis.