Severe endometriosis: low value of AMH did not affect oocyte quality and pregnancy outcome in IVF patients.

Arianna Pacchiarotti, Pacchiarotti A, A Pacchiarotti, Iaconianni P, P Iaconianni, Paola Iaconianni, Caporali S, S Caporali, Sabrina Caporali, Vitillo M, Marina Vitillo, M Vitillo, M Meledandri, Meledandri M, Gianluca Monaco, Monaco G, G. Monaco, C Sergio, C. Marcelo Sergio, Sergio C, M Boza, Boza M, Saccucci P, P. Saccucci
European review for medical and pharmacological sciences · 2020 · vol. 24(22) , pp. 11488–11495 · doi:10.26355/eurrev_202011_23790 · PMID:33275215 · W3106888354
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

In IVF patients with severe endometriosis and low AMH, oocyte yield was reduced, but embryo quality and pregnancy outcomes remained comparable to controls.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This pilot retrospective single-center study evaluated 50 IVF/ICSI cycles in patients younger than 37 with severe endometriosis, assessing whether low anti-Müllerian hormone (AMH) measured within 3 months before stimulation was associated with impaired oocyte yield, oocyte/embryo quality, and clinical outcomes, compared with 84 control patients without endometriosis and with normal AMH. Patients with severe endometriosis and AMH ≤1.1 ng/mL had significantly fewer retrieved oocytes and a lower proportion of mature (MII) oocytes than controls, but embryo morphology, implantation rate, and pregnancy rate were comparable between groups. The authors’ main caveat is that this was a small pilot analysis with retrospective data from a single center. This paper is centrally about endometriosis — it tests whether low AMH in severe endometriosis affects IVF/ICSI oocyte yield, embryo quality, and pregnancy outcomes.

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Abstract

OBJECTIVE: The aim of this pilot study was to determine whether the low anti-müllerian hormone (AMH) serum level, due to severe endometriosis, was associated with diminished oocyte yield, poor oocyte/embryo quality and reduced in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) clinical outcomes in young patients (<37 years old). PATIENTS AND METHODS: A total of 50 IVF cycles of patients younger than 37 with severe endometriosis were retrospectively analyzed in a single center between November 2016 and July 2018. The clinical outcome was then compared to a control group of 84 patients with no story of endometriosis and normal AMH value. AMH value was evaluated within three months before the stimulation. In these two groups, number and maturation of retrieved oocytes, embryo quality, and pregnancy outcomes were evaluated and compared using Student's t-test and Fisher's test. RESULTS: The number of oocytes retrieved per cycle and the percentage of mature oocytes (MII) were significantly lower (p 1.1 ng/ml (Group B; 6.9±4.6 retrieved oocytes, 83% MII). On the other hand, embryo morphology, implantation rate (31% vs. 33%; p = 0.833) and pregnancy rate (50% vs. 49%; p = 1) were comparable in the two groups. CONCLUSIONS: This study shows that younger patients with an impairment of the ovarian reserve due to severe endometriosis, displayed a diminished oocyte yield but not a reduction in embryo quality and pregnancy outcomes. These results suggest that serum AMH levels should not be adopted as a criterion for discouraging these patients from undergoing IVF/ICSI treatments.
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Objective

The aim of this pilot study was to determine whether the low anti-müllerian hormone (AMH) serum level, due to severe endometriosis, was associated with diminished oocyte yield, poor oocyte/embryo quality and reduced in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) clinical outcomes in young patients (<37 years old). PATIENTS AND METHODS: A total of 50 IVF cycles of patients younger than 37 with severe endometriosis were retrospectively analyzed in a single center between November 2016 and July 2018. The clinical outcome was then compared to a control group of 84 patients with no story of endometriosis and normal AMH value. AMH value was evaluated within three months before the stimulation. In these two groups, number and maturation of retrieved oocytes, embryo quality, and pregnancy outcomes were evaluated and compared using Student’s t-test and Fisher’s test.

Results

The number of oocytes retrieved per cycle and the percentage of mature oocytes (MII) were significantly lower (p 1.1 ng/ml (Group B; 6.9±4.6 retrieved oocytes, 83% MII). On the other hand, embryo morphology, implantation rate (31% vs. 33%; p = 0.833) and pregnancy rate (50% vs. 49%; p = 1) were comparable in the two groups.

Conclusions

This study shows that younger patients with an impairment of the ovarian reserve due to severe endometriosis, displayed a diminished oocyte yield but not a reduction in embryo quality and pregnancy outcomes. These results suggest that serum AMH levels should not be adopted as a criterion for discouraging these patients from undergoing IVF/ICSI treatments. Free PDF DownloadThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License To cite this article A. Pacchiarotti, P. Iaconianni, S. Caporali, M. Vitillo, M. Meledandri, G. Monaco, C. Sergio, M. Boza, P. Saccucci Severe endometriosis: low value of AMH did not affect oocyte quality and pregnancy outcome in IVF patients Eur Rev Med Pharmacol Sci Year: 2020 Vol. 24 - N. 22 Pages: 11488-11495 DOI: 10.26355/eurrev_202011_23790 Publication History Published online: 27 Nov 2020

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Fertilization in Vitro Oocytes Adult Anti-Mullerian Hormone Anti-Mullerian Hormone Endometriosis Female Humans Oocytes Oocytes Pregnancy Severity of Illness Index

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