Diagnostic value of serum miR-4677-3p combined with ultrasound in endometriosis

Jiancai Chen, Xiaojie Shen, Yuanyuan Li, Jingsi Ma, Xiaowei Shen
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2026 · vol. 42(1) , pp. 2693409 · doi:10.1080/09513590.2026.2693409 · PMID:42605867 · W7203627651
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Combining serum miR-4677-3p levels with ultrasound parameters significantly improves the diagnostic accuracy for endometriosis, achieving an area under the curve of 0.925 compared to 0.863 for miR-4677-3p alone.

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Abstract

OBJECTIVE: Endometriosis faces diagnostic delays due to the lack of tools for diagnostic evaluation. The value of miR-4677-3p combined with ultrasound in the diagnosis of endometriosis. METHODS: 110 healthy subjects and 110 endometriosis patients were recruited. miR-4677-3p level was detected by qRT-PCR. Color Doppler ultrasound was used to measure uterine artery blood flow parameters. Pearson analysis was applied to explore the correlation between miR-4677-3p and blood flow parameters. ROC curve was used to evaluate the diagnostic value. Logistic regression analysis was performed to identify risk factors. RESULTS: miR-4677-3p serum expression in endometriosis patients was upregulated, EDV and PSV were decreased, while PI and RI were increased. miR-4677-3p level was negatively correlated with RI and PI, and positively correlated with EDV and PSV. miR-4677-3p has diagnostic value for endometriosis, with an AUC of 0.863. After combination with ultrasound parameters, the AUC increased to 0.925, indicating a superior diagnostic value for endometriosis. Aberrantly expressed miR-4677-3p, dysmenorrhea, and CA125 as risk factors. CONCLUSION: The combined application of serum miR-4677-3p and ultrasound parameters can improve the diagnostic efficiency of endometriosis, providing a clinical tool for the accurate identification of the disease.

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MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis MicroRNAs MicroRNAs MicroRNAs MicroRNAs MicroRNAs MicroRNAs MicroRNAs Adult Adult Adult Adult

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