Study on therapeutic mechanism of Neiyifang in treating endometriosis

Chaoqin Yu, Cai Zai-long, Zailong Cai, Yuhuan Liu, Wang Da-zeng, Wang Zu-qian
In: Chinese Journal of Integrative Medicine · 2003 · vol. 9(2) , pp. 88–92 · doi:10.1007/bf02838554 · W2353394061
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-11 ⓘ

Neiyifang improved endometriosis symptoms by altering plasma β-endorphin and prostaglandin levels in patients.

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This paper evaluated the clinical effects of Neiyifang (NYF) in 104 patients with endometriosis across three menstrual cycles, measuring peripheral plasma β-endorphin (β-EP) in follicular, luteal, and menstrual stages and assaying multiple menstrual prostaglandins (PGF2α, PGE2, thromboxane B2, and 6-keto-PGF1α) by radioimmunoassay, compared with 15 healthy controls. Patients receiving NYF had an overall effective rate of 81.3% with significant improvement in symptoms and physical signs, and during the menstrual stage β-EP and the 6-keto-PGF1α/TXB2 ratio were increased while PGF2α and PGE2 were reduced (all reported P<0.05). The study also found that patients with endometriosis had lower β-EP and disturbed prostaglandin profiles versus controls, and that higher PGE2 levels were associated with more severe menalgia. The limitation explicitly noted is the small healthy-control comparison size and that the mechanistic work is based on plasma β-EP and prostaglandin levels rather than direct tissue or causal pathway confirmation. This paper is centrally about endometriosis — it tests Neiyifang’s therapeutic effect and links changes in β-endorphin and prostaglandin regulation to menalgia in endometriosis.

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Abstract

Objective: To observe the clinical effect of Neiyifang (NYF) in treating endometriosis and to explore its therapeutic mechanism through observing its influence on plasma β-endorphin (β-EP) in different menstrual stages and levels of prostaglandins (PGs) in menstruation.Methods:NYF was administered to 104 patients with endometriosis one dose daily with 3 successive menstrual cycles as one therapeutic course. Peripheral blood β-EP level in follicular, luteal and menstrual stages, as well as PGF2α, PGE2, thromboxane B2 and 6-keto-PGFl α levels in menstrual stage were detected by RIA, and controlled with those in 15 healthy persons.Results: (1) The total effective rate of NYF was 81.3% and it showed significant effect in improving patients’ clinical symptoms and physical signs; (2) In menstrual stage, the levels of β-EP, 6-keto-PGFα/ TXB2 were lower(P <0.05) and levels of PGF2α, PGE2, TXB2 and 6-keto-PGF1α were higher (P< 0. 05) in patients than those in control, and the higher the level of PGE2, the severer the menalgia, (3) NYF could increase levels of β-EP, 6-keto-PGF1α, and reduce levels of PGF2α, PGE2α in menstrual stage of patients (all P<0.05).Conclusion: (1) NYF has good clinical effect in treating endometriosis; (2) Patients’ symptom of menalgia is closely related with the excessive high levels of PGF2α and PGE2, PGI2/TXA2 ratio disturbance, and excessive low level of β-EP; (3) NYF could significantly decrease the PGE2, PGF1α levels, increase the 6-keto-PGF1α/TXB2 ratio and the level of β-EP, so as to alleviate the menalgia in patients with endometriosis. Similar content being viewed by others

References

Goldman MB, Cramer DW. The epidemiology of endometriosis. Prog Clin Biol Res 1990;323: 15–31. Strathy JH, MolgaardCA, Coulam CB, et al. Endometriosis and infertility: a laparoscopic study of endometriosis among fertile and infertile women. Fertil Steril 1982; 38: 667–672. Andersch B, Milson I. An epidemiological study of young women with dysmenorrhea. Am J Obstet Gynecol 1982; 144: 655. Third Academic Conference of Special Committee of Obstetrics and Gynecology, Chinese Association of the Integration of Traditional and Western Medicine. Standard for diagnosis and treatment of endometriosis, pregnant hypertension syndrome and female infertility by integrated traditional Chinese and western medicine (draft). CJIM (Chin) 1991; 11(6): 376. LI JJ. β-endorphin in field of obstetrics and gynecology. Pract J Obstet & Gynecol 1990;6(3): 155. Nagamasa M, Chiaki L, Yorito Y, et al. Increased killer inhibitory receptor KIR2DL1 expression among natural killer cells in women with pelvic endometriosis. Fertil Steril 2002; 77(2): 297–302. Nataraj C, Thomas DW, Tilley SL, et al. Receptors for prostaglandin E2 that regulate cellular immune responses in the mouse. J Clin Invest 2001; 108(8): 1229–1235. Scandella E, Ying Men, Gillessen S, et al. Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-dirived dendritic cells. Blood 2002; 100 (4): 1354–1361. Author information Authors and Affiliations Corresponding author Additional information This item was supported by National Funds of Natural Sciences(No. 30070942) Rights and permissions About this article Cite this article Chao-qin, Y., Zai-long, C., Yu-huan, L. et al. Study on therapeutic mechanism of Neiyifang in treating endometriosis. Chin. J. Integr. Med. 9, 88–92 (2003). https://doi.org/10.1007/BF02838554 Received: Issue date: DOI: https://doi.org/10.1007/BF02838554

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