THE MODERN STATE OF THE PROBLEM OF LOCAL IMMUNE DISORDERS IN PATIENTS WITH ADENOMYOSIS

Genital endometriosis is one of the most common proliferative diseases, whose frequency in women of reproductive age fluctuates from 10 to 60%. Immunity violations occupy a leading place in the development of genital endometriosis, but it is not clear whether they are initially or developing during the progression of the disease. The small number of studies of the role of immunity with adenomyosis, including congenital forms, the difficulties of correction of immune disorders in this pathology, the purpose of the work was to study the state of local immune disorders in patients with adenomyosis. MATERIALS AND METHODS. 55 patients were examined, which were divided into two groups. The group (control) amounted to 15 (27.3%) healthy fertile women. At the II group (the main) included 40 (72.7%) patients with adenomyosis І degree of spread. RESEARCH RESULTS AND THEIR DISCUSSION. In the process of conducting immunological research in patients with adenomyosis, changes are established at the local level in the content of humoral factors in cervical mucus. Disorders of congenital immunity are established, manifested in the activation of the complement system, pro-inflammatory cytokines under imbalance in the content of anti-inflammatory cytokines, an increase in the level of S-IgA, IgA, IgG, lysozyme, as well as the increased expression of TGF-β. CONCLUSIONS. The data obtained indicate signs of immune inflammation, leading to the decline of immune control, creating conditions for the possible invasion of endometrial cells into the adjacent myometrium. The results of the study are important to expand the ideas about the pathogenesis of this disease, as well as to determine the risk of progressional flow of adenomise at its initial stage.