Thickened endometrium in the postmenopausal woman: sonographic-pathologic correlation.
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Abstract
A correlative sonographic and histopathologic analysis was performed in 35 postmenopausal women with greater than 5-mm thickening of the endometrium at pelvic sonography. Women undergoing estrogen replacement were excluded from study. Four distinct sonographic patterns were encountered. Pattern 1 consisted of echogenic endometrium with small cysts (endometrial polyp with cystic hyperplasia [n = 9], atrophic endometrium with cystically dilated glands [n = 5], and atrophic endometrium [n = 3] at microscopic examination). Pattern 2 was homogeneous echogenic endometrium (proliferative endometrium [n = 3] and adenomyomatous polyp [n = 1]). Pattern 3 was irregular, inhomogeneous endometrium with ill-defined hypoechoic areas (endometrial carcinoma [n = 5], complex hyperplasia with atypia [n = 1], blood clots [n = 1], and atrophic endometrium with eosinophilic metaplasia [n = 1]). Pattern 4 was thin endometrium with fluid in the endometrial cavity (scant atrophic endometrium [n = 6]). Thus, an endometrial thickness of greater than 5 mm in postmenopausal women is associated with a variety of pathologic conditions. Subclassification of sonographic patterns may be helpful in differentiating benign cystic atrophy or cystic endometrial hyperplasia from malignant endometrial lesions.
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Cited by (16)
- Endometrial thickness and its diagnostic utility in postmenopausal women: A retrospective analysis of ultrasound and histopathological findings 2025
- Methods of Endometrial Evaluation 2018
- Avaliação ultrassonográfica no espessamento endometrial: revisão de literatura 2017
- Benign Diseases of the Uterus 2014
- Pelvic Imaging in Reproductive Endocrinology 2013
- Benign Diseases of the Female Genital Tract 2010
- Pelvic Imaging in Reproductive Endocrinology 2009
- Imagerie des méno-métrorragies 2008
- Radiographic imaging techniques for the diagnosis of abnormal uterine bleeding 2000
- Abnormal uterine cavity: differential diagnosis with MR imaging 1999
- Prediction of Benign and Malignant Endometrial Disease: Hysterosonographic-Pathologic Correlation 1999
- Magnetic Resonance Imaging Versus Ultrasound in the Assessment of Benign Uterine Lesions 1998
- Transvaginal ultrasonographic measurement of endometrial thickness in postmenopausal women receiving estrogen replacement therapy 1997
- Transvaginal ultrasonography and the progestogen challenge test in postmenopausal endometrial evaluation 1997
- Endometrial status in post-menopausal women on long-term continuous combined hormone replacement therapy (Kliofem®) a comparative study of endometrial biopsy, outpatient hysteroscopy and transvaginal ultrasound 1997
- Sonographic evaluation of the uterus in postmenopausal women receiving tamoxifen: characterization of mid-uterine abnormalities 1996
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