Comment on "Deciphering the Molecular Crosstalk of Endoplasmic Reticulum Stress and Immune Infiltration in Endometriosis"

Sah S, Saraswati Sah, Renu Sah, Sah R
American journal of reproductive immunology (New York, N.Y. : 1989) · 2025 · vol. 94(3) , pp. e70158 · doi:10.1111/aji.70158 · PMID:40948312 · W4414167231
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This commentary critiques a prior study investigating the molecular interplay between endoplasmic reticulum stress and immune infiltration within endometriotic tissue. The authors highlight methodological concerns regarding the statistical analysis, specifically focusing on the application and interpretation of receiver operating characteristic curves used to evaluate diagnostic accuracy. By pointing out potential flaws in how these metrics were applied to assess the relationship between cellular stress markers and immune cell presence, the comment aims to refine the understanding of the original findings. This paper is centrally about endometriosis — it serves as a critical peer commentary on the pathophysiological mechanisms of endometrial lesions.

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The authors declare no financial and no non-financial interests relevant to this study. The authors have nothing to report.
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Department of Medicine, Dr. D. Y. Patil Dental College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed-to-be-University), Pimpri, Pune, Maharashtra, India Contribution: Writing - original draft, Writing - review & editing Department of Medicine, Dr. D. Y. Patil Dental College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed-to-be-University), Pimpri, Pune, Maharashtra, India Contribution: Writing - original draft, Writing - review & editing Sah, S. and Sah, R. (2025), Comment on “Deciphering the Molecular Crosstalk of Endoplasmic Reticulum Stress and Immune Infiltration in Endometriosis”. Am J Reprod Immunol, 94: e70158. https://doi.org/10.1111/aji.70158 The authors declare no financial and no non-financial interests relevant to this study. Data Availability Statement The authors have nothing to report. References 1Y. Ma, C. Ha, R. Li, R. Zhang, and M. Li, “Deciphering the Molecular Crosstalk of Endoplasmic Reticulum Stress and Immune Infiltration in Endometriosis,” American Journal of Reproductive Immunology93 (2025): e70092, https://doi.org/10.1111/aji.70092. 2P. W. Chang and T. B. Newman, “Receiver Operating Characteristic (ROC) Curves: The Basics and beyond,” Hospital Pediatrics14, no. 7 (2024): e330–e334, https://doi.org/10.1542/hpeds.2023-007462. Total unique accesses to an article’s full text in HTML or PDF/ePDF format.More metric information Scite metrics Explore this article's citation statements on scite.ai Share QR Code Generating QR code QR code copied to clipboard! Something went wrong while generating your QR code. Please try again in a moment. If the issue persists, refresh the page or contact support. Export citation Unable to load citation data. Please try again in a moment. How to cite Elkins, L. J., & Spiegelman, M. (2021). pyUserCalc: A revised Jupyter notebook calculator for uranium-series disequilibria in basalts. Earth and Space Science, 8, e2020EA001619. https://doi.org/10.1029/2020EA001619 How to cite text copied to clipboard! Download Citation If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click on download. This feature enables you to download the bibliographic information (also called citation data, header data, or metadata) for the articles on our site. Citation manager file format Use the dropdown list to choose how to format the bibliographic data you're harvesting. Several citation manager formats are available, including EndNote and BibTex. You can then copy the formatted citation (as displayed) or download it as file, to your device. If the RefWorks format is chosen, the 'Download' button will be replaced with an option to directly export to RefWorks Please check your email for instructions on resetting your password. If you do not receive an email within 10 minutes, your email address may not be registered, and you may need to create a new Wiley Online Library account. Request Username Can't sign in? Forgot your username? Enter your email address below and we will send you your username If the address matches an existing account you will receive an email with instructions to retrieve your username The full text of this article hosted at iucr.org is unavailable due to technical difficulties.

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endometriosis

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