PENGARUH EKSTRAK ETANOL KULIT BUAH NAGA MERAH \n(HYLOCEREUS POLYRHIZUS) BERBAGAI DOSIS TERHADAP KADAR \nTUMOR NECROSIS FACTOR-α, JUMLAH MAKROFAG, DAN EKSPRESI \nMATRIX METALLOPROTEINASE-9 \nPenelitian Eksperimental Pada Hewan Coba Mencit Model Endometriosis

ANINDYA HAPSARI, 011514653001
2017 · W7042457691
Lab / animal OA: green CC0
📄 Open PDF Full text JSON View on OpenAlex
⚙ AI-generated summary by qwen3.7-flash, 2026-10-19 ⓘ

Ethanol extract of red dragon fruit peel significantly reduced macrophage numbers and MMP-9 expression in a mouse endometriosis model, although it did not significantly alter TNF-α concentrations.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-10-01 · read from full text ⓘ

This experimental study investigated the effects of varying doses of Hylocereus polyrhizus peel ethanol extract on inflammatory markers in a mouse model of endometriosis. Researchers induced endometriosis in thirty female mice and administered oral doses of the extract over fourteen days, subsequently analyzing peritoneal fluid and lesion tissues for TNF-α concentration, macrophage counts, and MMP-9 expression. The results indicated that while TNF-α levels remained unchanged across groups, both macrophage numbers and MMP-9 expression were significantly reduced in the treatment groups compared to controls. This paper is centrally about endometriosis — specifically evaluating the anti-inflammatory potential of a botanical extract on disease progression markers in an animal model.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

On endometriosis, macrophage and TNF-α are found in higher concentration. TNF- \nα can activate NF-κB pathway and raise the expression of MMP-9 and MCP-1’s \ngenes, which are associated with endometriosis progressivity. NF-κB pathway can \nbe blocked by Hylocereus polyrhizus peel. The objective of this study was to know \nthe effect of Hylocereus polyrhizus peel ethanol extract at dose 0.25; 0.5; and 1 \nmg/g BW on TNF-α concentration, number of macrophage, and MMP-9 expression \non mouse model of endometriosis. This study was a laboratory experimental \nresearch. Thirty female mice were used as samples and divided into 5 groups: 1 \npositive control, 1 negative control, and 3 treatment groups. Positive control and \ntreatment groups were induced as model of endometriosis for 14 days. The next 14 \ndays, Na-CMC 0.5% was given to both control groups, while Hylocereus polyrhizus \npeel ethanol extract dose 0.25; 0.5; and 1 mg/g BW were given to treatment groups \norally. Peritoneal fluid and endometriotic lesion were examined. Result showed that \nthere was no significantly differences on TNF-α concentration among \nendometriosis groups (p=0.582). While, there were significantly differences on \nnumber of macrophage and MMP-9 expression among groups (p<0.05). In \nconclusion, the number of macrophage and MMP-9 expression are significantly \nlower in groups treated with Hylocereus polyrhizus peel ethanol extract, but the \nTNF-α concentration is not.
Full text 1,940 characters · extracted from oa-pdf · 2 sections · click to expand

Abstract

EFFECT OF VARIOUS DOSES OF HYLOCEREUS POLYRHIZUS PEEL ETHANOL EXTRACT TO TUMOR NECROSIS FACTOR-α CONCENTRATION, NUMBER OF MACROPHAGE, AND MATRIX METALLOPROTEINASE-9 EXPRESSION Experimental Study in Mouse Model of Endometriosis ANINDYA HAPSARI On endometriosis, macrophage and TNF-α are found in higher concentration. TNF- α can activate NF-κB pathway and raise the expression of MMP -9 and MCP-1’s genes, which are associated with endometriosis progressivity. NF-κB pathway can be blocked by Hylocereus polyrhizus peel. The objective of this study was to know the effect of Hylocereus polyrhizus peel ethanol extract at dose 0.25; 0. 5; and 1 mg/g BW on TNF-α concentration, number of macrophage, and MMP-9 expression on mouse model of endometriosis. This study was a laboratory experimental research. Thirty female mice were used as samp les and divided into 5 groups: 1 positive control, 1 negative control, and 3 treatment groups. Positive control and treatment groups were induced as model of endometriosis for 14 days. The next 14 days, Na-CMC 0.5% was given to both control groups, while Hylocereus polyrhizus peel ethanol extract dose 0.25; 0.5; and 1 mg/g BW were given to treatment groups orally. Peritoneal fluid and endometriotic lesion were examined. Result showed that there was no significantly differences on TNF -α concentration among endometriosis groups (p=0.582). While, there were significantly differences on number of macrophage and MMP -9 expression among groups (p<0.05). In conclusion, the number of macrophage and MMP -9 expression are significantly lower in groups treated with Hylocereus polyrhizus peel ethanol extract, but the TNF-α concentration is not.

Keywords

Hylocereus polyrhizus peel ethanol extract, endometriosis, TNF -α, macrophage, MMP-9

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-pdf ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

openalex
last seen: 2026-05-11T07:31:38.665836+00:00
License: CC0 · commercial use OK