Adhesion development and the expression of endothelial nitric oxide synthase

Svinarich DM, D M Svinarich, F M Zaher, Zaher FM, Holmdahl L, L Holmdahl, N. Chegini, Chegini N, B Gonik, Gonik B, M P Diamond, Diamond MP, PHAMUS Group. Peritoneal Healing and Adhesion Multi-University Study
Infectious diseases in obstetrics and gynecology · 2001 · vol. 9(2) , pp. 113–6 · doi:10.1155/s1064744901000199 · PMID:11495551 · PMC1784645
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Researchers quantified endothelial nitric oxide synthase mRNA levels in skin, subcutaneous tissue, peritoneum, and adhesions, finding detectable expression in adhesions that suggests a role in their formation and maintenance.

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Abstract

OBJECTIVE: This study was conducted to determine whether nitric oxide (NO), a potent vasodilator and inhibitor of thrombus formation, is involved in the formation and maintenance of adhesions. METHODS: Skin, subcutaneous tissues, peritoneum and adhesions were collected from surgical patients and total RNA was isolated. Quantitative reverse transcription polymerase chain reaction (QRT-PCR) was performed to quantitate endothelial nitric oxide synthase (eNOS) and beta-actin mRNA levels. RESULTS: eNOS mRNA levels for skin, subcutaneous tissue, peritoneum and adhesions were < or = 3.12 x 10(-4), < or = 3.12 x 10(-4), 6.24 x 10(-4) and 2.5 x 10(-3) attomoles/microl, respectively. Beta-actin mRNA levels for all tissues were between 1.25 x 10(-1) and 6.25 x 10(-2) attomoles/microl. CONCLUSION: eNOS mRNA can be identified in tissue adhesions, and may therefore play a role in adhesion formation and maintenance.

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MeSH descriptors

Nitric Oxide Synthase Peritoneal Diseases RNA, Messenger Tissue Adhesions Actins Actins Endothelium Endothelium Female Gene Expression Profiling Humans Nitric Oxide Synthase Peritoneal Diseases Peritoneal Diseases Peritoneum Peritoneum Pilot Projects Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger Skin

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europepmc
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