Diagnóstico diferencial: Tumor neuroendócrino de apêndice e endometriose, um relato de caso

Diagnóstico diferencial: Tumor neuroendócrino de apêndice e endometriose, um relato de caso DOI: https://doi.org/10.70164/jmbr.v3i2.1146Keywords: Tumor neuroendócrino do apêndice, Endometriose, Apendicectomia, Diag-nóstico diferencial, Imuno-histoquímica, Relato de caso.Abstract Os tumores neuroendócrinos do apêndice são neoplasias raras, frequentemente diagnosticadas de forma incidental, enquanto a endometriose profunda é condição comum em mulheres jovens. Relata-se o caso de paciente de 24 anos, com endometriose em acompanhamento, que apresentou achado nodular atípico em exame de imagem. Foi submetida à videolaparoscopia com apendicectomia alargada, cujo exame anatomopatológico revelou tumor neuroendócrino bem diferenciado do apêndice, grau G2 (Ki-67 entre 5% e 8%), estadiamento pT3, com margens livres. Exames complementares não evidenciaram metástases, sendo instituído seguimento clínico multidisciplinar. O caso ressalta a importância do diagnóstico diferencial entre endometriose apendicular e tumor neuroendócrino, bem como o papel fundamental da análise histopatológica para definição terapêutica adequada. References AL‑SHULER, Paulina C.; SCHULTZE, Peter M. Diagnosis of appendiceal neuroendocrine tumors following incidental appendectomy during benign gynecologic laparoscopic surgeries: a case series. Cureus, v. 15, n. 6, e41135, 2023. ANDRINI, Elisa et al. An update on appendiceal neuroendocrine tumors. Current Treatment Options in Oncology, v. 24, p. 742–756, 2023. BECKER, S. et al. Appendiceal involvement in en-dometriosis: systematic review and case series. Fertility and Sterility, v. 107, n. 1, p. 134–142, 2017. CHARLTON, J. et al. Appendiceal endometriosis: clinical presentation and surgical management. Journal of Minimally Invasive Gynecology, v. 22, n. 5, p. 845–851, 2015. FERRERO, S. et al. Endometriosis and appendiceal tumors: diagnostic challenges. European Journal of Obstetrics & Gynecology and Reproductive Bio-logy, v. 251, p. 93–99, 2020. GIUDICE, L. C. KAO, L. C. Endometriosis. The Lancet, v. 394, n. 10197, p. 1946–1960, 2020. HADDAD, Raphael Federicci et al. Nodular image in the appendix observed on ultrasound: endometri-osis or neuroendocrine neoplasia? Revista Brasileira de Ginecologia e Obstetrícia, 2024. HENDRICKSON, M. R. et al. Appendiceal endome-triosis: a clinicopathologic study. Obstetrics & Gynecology, v. 71, n. 4, p. 520–524, 1988. HOLMAGGER, Pernille et al. Appendiceal neuroen-docrine neoplasms: an update for 2023. Current Oncology Reports, v. 26, n. 2, p. 114–120, 2024. KÖHLER, C. et al. Incidental appendiceal neuroen-docrine tumors in endometriosis surgery. Gynecolo-gic Oncology, v. 161, n. 2, p. 432–438, 2021. MODLIN, I. M.; SANDOR, A. Gastrointestinal car-cinoid tumors: an analysis of 13,715 cases. Cancer, v. 86, n. 4, p. 794–809, 1999. MODLIN, I. M. et al. A 50‑year analysis of 13,715 carcinoid tumors. Cancer, v. 97, n. 4, p. 934–959, 2003. NEZHAT, C. et al. Imaging and surgical considera-tions in intestinal endometriosis. Fertility and Steri-lity, v. 114, n. 3, p. 505–516, 2020. PANG, L. et al. Epidemiology and prognosis of appendiceal neuroendocrine tumors. BMC Cancer, v. 17, p. 642, 2017. PAPE, U. F. et al. Neuroendocrine tumors of the appendix: clinical and diagnostic features. Endocri-ne Connections, v. 9, n. 2, p. 98–110, 2020. RAMAGE, J. K. et al. Guidelines for the management of gastroenteropancreatic neuroendocrine tumors. Gut, v. 69, n. 1, p. 6–28, 2020. REIS, Aline et al. Deep infiltrating endometriosis: clinical management and surgical outcomes. Best Practice & Research Clinical Obstetrics & Gynaeco-logy, v. 84, p. 76–90, 2023. SOMIGLIANA, E. et al. Appendiceal involvement in women undergoing surgery for endometriosis: multicenter study. Human Reproduction, v. 35, n. 3, p. 621–630, 2020. WORLD HEALTH ORGANIZATION – WHO. Classification of Tumours: Digestive System Tu-mours. 5. ed. Lyon: IARC, 2019. WORLD MEDICAL ASSOCIATION – WMA. Declara-ção de Helsinki: Princípios Éticos para Pesquisas Médicas Envolvendo Seres Humanos. 2013. YAO, J. C. et al. Epidemiology of gastroentero-pancreatic neuroendocrine tumors in the United States. Journal of Clinical Oncology, v. 26, n. 18, p. 3063–3072, 2008. ZANELLA, R. et al. Appendiceal endometriosis and neuroendocrine tumor: report of a rare association. European Journal of Gynaecological Oncology, v. 31, n. 2, p. 201–203, 2010. ZHANG, He‑wei et al. Analysis of surgical treatment of appendix neuroendocrine neoplasms — 17 years of single‑center experience. World Journal of Surgi-cal Oncology, v. 21, art. 150, 2023. Downloads Published How to Cite Issue Section License Copyright (c) 2026 Lavínia Lopes Bamberg, Felipe Vilanova de França Santana, Antonella Hoffman Maciel, Maria Júlia de Azevedo Barreira de Azevedo; Bruna Correia Sarno; Bruna de Cássia Ribas Benfica dos Santos This work is licensed under a Creative Commons Attribution 4.0 International License.