Spontaneous pregnancy following intra-ovarian platelet-rich plasma administration in poor ovarian responders according to the POSEIDON criteria: A cross-sectional study

Marzie Sanuie Farimani, Sanuie Farimani M, Amiri K, Kimia Amiri, Anvari Aliabad R, Roghayeh Anvari Aliabad
International journal of reproductive biomedicine · 2025 · vol. 23(8) , pp. 627–636 · doi:10.18502/ijrm.v23i8.19811 · PMID:41306715 · PMC12477538
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In a cross-sectional study of 596 poor ovarian responders treated with intra-ovarian platelet-rich plasma, the spontaneous pregnancy rate was 8.39%, with significant differences in age, BMI, and hormonal markers observed between pregnant and non-pregnant groups.

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This cross-sectional study examined 42 women with poor ovarian response who achieved spontaneous pregnancy after receiving intra-ovarian platelet-rich plasma injections. The researchers analyzed demographic and clinical variables across POSEIDON groups, finding significant differences in age, body mass index, anti-Müllerian hormone levels, and follicle counts among the subgroups. A major limitation noted is that the higher prevalence of pregnancies in certain groups likely reflects larger population sizes within those categories rather than increased susceptibility to the treatment. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

BACKGROUND: Female infertility, especially in those individuals with poor ovarian response (POR), is a challenge in the field of infertility and sterility. Recently, intra-ovarian platelet-rich plasma (IO-PRP) administration has been suggested as a possible co-treatment. OBJECTIVE: This study aimed to investigate the biodemographic characteristics of individuals who experienced spontaneous pregnancy following IO-PRP. MATERIALS AND METHODS: In this cross-sectional study, out of 1548 women diagnosed with POR who underwent IO-PRP, 596 individuals who completed their 2-yr follow-up period, were included. Different types of demographic and pre-intervention laboratory data (blood levels of anti-Müllerian hormone, luteinizing hormone, follicle-stimulating hormone, estradiol, prolactin, and their spouses' sperm analysis results) were collected from the files. Each individual was classified into a certain group according to the POSEIDON criteria, and their data were compared. RESULTS: The results showed that 50 (8.39%) spontaneous pregnancies were observed. However, 8 were excluded from further analyses due to missing data in their critical variables. The most prevalent POSEIDON group was 4, with a prevalence of 17/42 (40.47%). Among the POSEIDON groups, covariates including the age of the individuals and their spouses, body mass index, anti-Müllerian hormone, and antral follicle/oocytes count following the latest IO-PRP significantly differed (p < 0.001, p < 0.001, p = 0.039, p < 0.001, and p = 0.022, respectively). CONCLUSION: The spontaneous pregnancy rate following IO-PRP among women with POR was low. However, significant differences in biodemographic and hormonal characteristics were observed between the groups with and without spontaneous pregnancy which could be useful in leading future studies on this subject.
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M. Sanuie Farimani and R. Anvari Aliabad had full access to all of the data in the study and took responsibility for the integrity of the data and the accuracy of the data analysis. Concept and design: M. Sanuie Farimani and R. Anvari Aliabad. Acquisition, analysis, or interpretation of data K. Amiri and R. Anvari Aliabad. Drafting of the manuscript: K. Amiri and R. Anvari Aliabad. Critical revision of the manuscript for important intellectual content: All authors. Statistical analysis: K. Amiri. Supervision: M. Sanuie Farimani and R. Anvari Aliabad.

Coi Statement

The authors declare that there is no conflict of interest.

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