Danazol (an antigonadotropin) in the treatment of catamenial pneumothorax

T Uemura, Tsuguo Uemura, Uemura T, Akemi JVIatsuyama, A Matsuyama, Matsuyama A, Minaguchi H, H. Minaguchi, H Ikeda, Hirotada Ikeda, Ikeda H
Asia-Oceania journal of obstetrics and gynaecology · 1985 · vol. 11(1) , pp. 81–86 · doi:10.1111/j.1447-0756.1985.tb00051.x · PMID:4015522 · W2144365299
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This paper reports two cases of catamenial pneumothorax successfully treated with danazol, with one patient remaining asymptomatic for 20 months after therapy following surgical recurrence.

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Abstract

Abstract Two cases of catamenial pneumothorax treated with danazol, an isoxazole derivative of 17α‐ethinyl testosterone, are reported. The first patient, a 44‐year‐old woman who had had 31 attacks of spontaneous pneumothorax at the onset of menstruation in the past 7 years, was given 400 mg danazol daily for 6 months. Episodes did not reoccur during the treatment or for 5 months after the treatment, though ovulation was observed in the first menstrual cycle after the treatment. The second patient was a 33‐year‐old woman who had had recurrent right‐sided chest pains related to the onset of menses. The endometrial implants in the diaphragm were excised but a right pneumothorax recurred at the first menstrual period after operation. After 4 months of therapy with danazol she has been asymptomatic for 20 months. Danazol therapy seems to be more effective on this disease and to have less side effects than other ovulation inhibiting drugs.

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Condition tags

endometriosis

MeSH descriptors

Danazol Menstruation Menstruation Pneumothorax Pregnadienes Adult Adult Danazol Danazol Diaphragm Diaphragm Endometriosis Endometriosis Endometriosis Female Female Humans Humans Pneumoperitoneum Pneumoperitoneum

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