Pituitary desensitization for eight weeks after the administration of two distinct gonadotrophin-releasing hormone agonists

Matteo M, Maria Matteo, Ettore Caroppo, Orion Gliozheni, Gliozheni O, Domenico Carone, Carone D, Luca Maria Schonauer, Luca Maria Schonäuer, Vizziello G, Giovanni Vizziello, G Vizziello, Pantaleo Greco, Giuseppe D’Amato, Giuseppe D'Amato
European journal of obstetrics, gynecology, and reproductive biology · 2005 · vol. 126(1) , pp. 77–80 · doi:10.1016/j.ejogrb.2005.09.018 · PMID:16359772 · W2112070871
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This study investigated pituitary desensitization for eight weeks following the administration of two different gonadotrophin-releasing hormone agonists.

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Abstract

Objective(s)The objective was to evaluate the duration of pituitary desensitization after the administration of 3.5 mg of triptorelin (T) and leuprolin (L) depot preparations in patients with endometriosis.Study designTwo groups of 30 patients received, on 21st day of the cycle, 3.75 mg i.m. of triptorelin (T group), and of leuprolin acetate (L group). From the first to the eighth week following gonadotrophin-releasing hormone agonists (GnRH-a) administration both groups underwent pelvic ultrasound and serum follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) evaluation. Statistical analysis was performed using the ANOVA test and the median test. A p-value < 0.05 was considered significant.ResultsPituitary suppression was achieved from two to six and from two to seven weeks after the administration of 3.75 mg of leuprolin and triptorelin, respectively. FSH and LH serum levels were significantly higher in the L group than in the T group after the fourth week.ConclusionsLeuprolin and triptorelin depots (3.75 mg) promote satisfactory ovarian suppression lasting for six and seven weeks, respectively, after administration, with significantly different ambient levels of endogenous LH.

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Condition tags

endometriosis

MeSH descriptors

Delayed-Action Preparations Endometriosis Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Ovulation Inhibition Pituitary Gland Analysis of Variance Delayed-Action Preparations Endometriosis Estradiol Estradiol Female Follicle Stimulating Hormone Follicle Stimulating Hormone Gonadotropin-Releasing Hormone Humans Leuprolide Leuprolide Luteinizing Hormone Luteinizing Hormone

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