The Role of Matrix Metalloproteinase9 (MMP9) in Endometriosis

Amalia Amalia, Nusratuddin Abdullah, Umar Malinta
In: Indonesian Journal of Obstetrics and Gynecology · 2017 · pp. 203 · doi:10.32771/inajog.v5i4.559 · W2884555859
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This study found that higher expression of MMP-9 is significantly associated with higher stages of endometriosis in women undergoing laparoscopic surgery.

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This observational cross-sectional study investigated MMP-9 expression in endometriosis patients undergoing laparoscopic surgery at hospitals in Makassar between October 2015 and March 2016, analyzing 50 histopathology samples by immunohistochemistry. MMP-9 expression was compared across endometriosis stages using Mann–Whitney and chi-square tests. The authors found significantly higher MMP-9 expression in more advanced disease, with mean expression ranks of 16.68 for stages I–II versus 27.99 for stages III–IV (p=0.013), and a greater proportion of positive higher-grade expression in stages III–IV (p=0.043). This paper is centrally about endometriosis — it assesses how MMP-9 expression varies with endometriosis stage.

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Abstract

Objective: To investigate the role of MMP-9 expression in endometriosis. Methods: The study was conducted from October 2015 to March 2016, an observational study with cross-sectional design. Samples are all endometriosis patients who underwent laparoscopic surgery in Dr. Wahidin Sudirohusodo Hospital and several other hospitals in Makassar. Samples were stored and fixed in the Grand Medika Histopathology Laboratory Makassar for examination the expression of MMP-9 using immunohistochemical methods. Conducted an analysis of 50 samples, of which 11 samples of stage II, 21 stage III samples, and 18 samples of stage IV. The data obtained and analyzed statistically using Mann Whitney and Chi Square test with a significance level of p <0.05. Results: The results reported rankings mean the expression of MMP-9 in stage I-II = 16.68, stage III-IV 27.99 (p = 0.013). There were differences in the expression of MMP-9 based on the stage. Stage I-II endometriosis had a more positive 2 expression of MMP-9 (45.5%), stage III-IV endometriosis have more positive 3 expression of MMP-9 (59.0%). The results of chi square test (p = 0.043). Conclusion: Higher expression of MMP-9 is significantly associated with higher degree of endometriosis. Keywords: matrix metalloproteinase-9, stages of endometriosis
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Objective

To investigate the role of MMP-9 expression in endometriosis.

Methods

The study was conducted from October 2015 to March 2016, an observational study with cross-sectional design. Samples are all endometriosis patients who underwent laparoscopic surgery in Dr. Wahidin Sudirohusodo Hospital and several other hospitals in Makassar. Samples were stored and fixed in the Grand Medika Histopathology Laboratory Makassar for examination the expression of MMP-9 using immunohistochemical methods. Conducted an analysis of 50 samples, of which 11 samples of stage II, 21 stage III samples, and 18 samples of stage IV. The data obtained and analyzed statistically using Mann Whitney and Chi Square test with a significance level of p <0.05.

Results

The results reported rankings mean the expression of MMP-9 in stage I-II = 16.68, stage III-IV 27.99 (p = 0.013). There were differences in the expression of MMP-9 based on the stage. Stage I-II endometriosis had a more positive 2 expression of MMP-9 (45.5%), stage III-IV endometriosis have more positive 3 expression of MMP-9 (59.0%). The results of chi square test (p = 0.043).

Conclusion

Higher expression of MMP-9 is significantly associated with higher degree of endometriosis.

Keywords

matrix metalloproteinase-9, stages of endometriosis

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Condition tags

endometriosis

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