In vitro apoptosis effects of GnRHII on endometrial stromal cells from patients with endometriosis.
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Gonadotropin-releasing hormone II (GnRHII) was found to increase apoptosis in endometrial stromal cells from endometriosis patients, with a particularly significant effect on ectopic stromal cells.
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Abstract
PURPOSE: To study the effect of gonadotropin-releasing hormone II (GnRHII) on the cell apoptosis of ectopic, eutopic and normal endometrial stromal cells cultured in vitro from endometriosis patients, and to provide theoretical basis for exploring new treatments for endometriosis (EMs). METHODS: Ectopic, eutopic and normal endometrial stromal cells were isolated, cultured and identified in vitro, then treated with different concentrations of GnRHII (0, 10(-10) M, 10(-8) M and 10(-6) M). Cell apoptosis was detected by Hoechst staining and flow cytometry. RESULTS: GnRHII increased apoptosis in ectopic, eutopic and normal stromal cells in a dosage-dependent manner (P<0.05), and apoptosis of ectopic stroma cells was significantly higher than that of eutopic and normal cells (P0.05). CONCLUSION: GnRHII can significantly induce apoptosis in ectopic, eutopic and normal endometrial stromal cells from patients with endometriosis, especially to the ectopic.
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Cites (3)
- [Effect of progesterone on the secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 in human ectopic endometrial stromal cells]. 2005
- [Effects of medical treatment on apoptosis in eutopic endometrium of patients with endometriosis]. 2007
- Outcome of pregnancies after inadvertent exposure to GnRH agonist in early pregnancy. 2011
Cited by (2)
References (3)
- [Effect of progesterone on the secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 in human ectopic endometrial stromal cells]. via openalex
- [Effects of medical treatment on apoptosis in eutopic endometrium of patients with endometriosis]. via openalex
- Outcome of pregnancies after inadvertent exposure to GnRH agonist in early pregnancy. via openalex
Cited by (2)
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- europepmc
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- openalex
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- pubmed
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