Research in Benign Gynaecology

In: Introduction to Research Methodology for Specialists and Trainees · 2017 · pp. 235–254 · doi:10.1017/9781107585775.030 · W2736355734
book-chapter OA: closed CC0
Full text JSON View on OpenAlex View at publisher
AI-generated summary by claude@2026-06, 2026-06-06

This paper reviews current research in benign gynecology, covering topics from diagnostics to treatments and future directions.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

AI-generated deep summary by claude@2026-06, 2026-06-06 · read from full text

This paper is a chapter-length educational work that introduces research methodology for obstetrics and gynaecology specialists and trainees, covering topics such as time management, computer skills, information searching, critical appraisal, evidence-based medicine, clinical audit, study designs including randomized clinical trials, and research ethics and patient involvement. It outlines practical guidance for conducting and evaluating biomedical research, including aspects of data management, statistics, epidemiology, and how to write and present papers, with a stated caveat that no summary of findings is provided in the accessible preview because the content is methodological rather than an empirical study. The key contribution is the structured overview of how to plan, conduct, and report research across multiple domains of benign gynaecology and related areas. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Full text 14,941 characters · extracted from oa-doi-fallback · click to expand
- Introduction to Research Methodology for Specialists and Trainees - Introduction to Research Methodology for Specialists and Trainees - Copyright page - Contents - Contributors - Preface - Chapter 1 Research During Specialist Medical Training - Chapter 2 Time Management When Planning and Conducting Medical Research - Chapter 3 Computer Skills Required for Medical Research - Chapter 4 Computer Skills Required for Medical Research: Social Media - Chapter 5 Finding and Using Information in Your Research - Chapter 6 Critical Appraisal of the Medical Literature - Chapter 7 Evidence-based Medicine and Translating Research into Practice - Chapter 8 Clinical Audit for Quality Improvement - Chapter 9 A Journey of Exploration - Chapter 10 Randomised Clinical Trials - Chapter 11 Animal Research and Alternatives - Chapter 12 Genetic and Epigenetic Research - Chapter 13 ‘Omic’ Research - Chapter 14 Data Management in Medical Research - Chapter 15 Statistics in Medical Research - Chapter 16 Epidemiological Research - Chapter 17 Informing Patients, Consent, Governance and Good Clinical Practice - Chapter 18 Patient Involvement in Medical Research - Chapter 19 Research in the National Health Service - Chapter 20 Supervising Medical Research and Being Supervised - Chapter 21 Funding Medical Research - Chapter 22 The Purpose and Practice of Medical Research Meetings - Chapter 23 How to Present a Medical Research Paper - Chapter 24 How to Write a Medical Research Paper and Get It Accepted for Publication - Chapter 25 How to Write a Medical Thesis - Obstetrics and Gynaecology Supplement - B Research in Fetal Medicine - C Research in Maternal Medicine - D Research in Benign Gynaecology - E Research in Gynaecological Oncology - Index - References Published online by Cambridge University Press: 04 August 2017 Book contents - Introduction to Research Methodology for Specialists and Trainees - Introduction to Research Methodology for Specialists and Trainees - Copyright page - Contents - Contributors - Preface - Chapter 1 Research During Specialist Medical Training - Chapter 2 Time Management When Planning and Conducting Medical Research - Chapter 3 Computer Skills Required for Medical Research - Chapter 4 Computer Skills Required for Medical Research: Social Media - Chapter 5 Finding and Using Information in Your Research - Chapter 6 Critical Appraisal of the Medical Literature - Chapter 7 Evidence-based Medicine and Translating Research into Practice - Chapter 8 Clinical Audit for Quality Improvement - Chapter 9 A Journey of Exploration - Chapter 10 Randomised Clinical Trials - Chapter 11 Animal Research and Alternatives - Chapter 12 Genetic and Epigenetic Research - Chapter 13 ‘Omic’ Research - Chapter 14 Data Management in Medical Research - Chapter 15 Statistics in Medical Research - Chapter 16 Epidemiological Research - Chapter 17 Informing Patients, Consent, Governance and Good Clinical Practice - Chapter 18 Patient Involvement in Medical Research - Chapter 19 Research in the National Health Service - Chapter 20 Supervising Medical Research and Being Supervised - Chapter 21 Funding Medical Research - Chapter 22 The Purpose and Practice of Medical Research Meetings - Chapter 23 How to Present a Medical Research Paper - Chapter 24 How to Write a Medical Research Paper and Get It Accepted for Publication - Chapter 25 How to Write a Medical Thesis - Obstetrics and Gynaecology Supplement - B Research in Fetal Medicine - C Research in Maternal Medicine - D Research in Benign Gynaecology - E Research in Gynaecological Oncology - Index - References A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content. - Type - Chapter - Information - Publisher: Cambridge University PressPrint publication year: 2017 FIGO Committe for the Study of Ethical Aspects of Human Reproduction and Women’s Health. Ethical Issues in Obstetrics and Gynaecology. [PDF Report] 2012 [cited 2015 19/06/2015]; Available from: www.glowm.com/pdf/English%20Ethical%20Issues%20in%20Obstetrics%20and%20Gynecology.pdfGoogle Scholar Medical Research Council UK. Human Tissue and Biological Samples for Use in Research: Operational and Ethical Guidelines. MRC RSC Human Tissue Legislation Summaries 2014 [cited 2015 19/06/2015]; Available from: www.mrc.ac.uk/research/facilities/regulatory-support-centre/human-tissue/Google Scholar Kok, VC, Tsai, HJ, Su, CF, Lee, CK. The risks for ovarian, endometrial, breast, colorectal, and other cancers in women with newly diagnosed endometriosis or adenomyosis: A population-based study. Int J Gynecol Cancer. 2015 Jul;25(6):968–76.CrossRefGoogle ScholarPubMed Su, SY, Muo, CH, Sung, FC, Morisky, DE. Reduction of surgery rate in endometriosis patients who take Chinese medicine: A population-based retrospective cohort study. Complement Ther Med. 2014 Aug;22(4):632–9.CrossRefGoogle ScholarPubMed Upson, K, De Roos, AJ, Thompson, ML, et al. Organochlorine pesticides and risk of endometriosis: findings from a population-based case-control study. Environ Health Perspect. 2013 Nov-Dec;121(11–12):1319–24.CrossRefGoogle ScholarPubMed Wu, CY, Chang, WP, Chang, YH, Li, CP, Chuang, CM. The risk of irritable bowel syndrome in patients with endometriosis during a 5-year follow-up: A nationwide population-based cohort study. Int J Colorectal Dis. 2015 Jul;30(7):907–12.CrossRefGoogle ScholarPubMed Yu, HC, Lin, CY, Chang, WC, Shen, BJ, Chang, WP, Chuang, CM. Increased association between endometriosis and endometrial cancer: A nationwide population-based retrospective cohort study. Int J Gynecol Cancer. 2015 Mar;25(3):447–52.CrossRefGoogle ScholarPubMed Yuk, JS, Kim, YJ, Yi, KW, Tak, K, Hur, JY, Shin, JH. High rate of nickel allergy in women with endometriosis: A 3-year population-based study. J Obstet Gynaecol Res. 2015 Aug;41(8):1255–9.CrossRefGoogle ScholarPubMed Harris, HR, Chavarro, JE, Malspeis, S, Willett, WC, Missmer, SA. Dairy-food, calcium, magnesium, and vitamin D intake and endometriosis: A prospective cohort study. Am J Epidemiol. 2013 Mar 1;177(5):420–30.CrossRefGoogle ScholarPubMed Shah, DK, Correia, KF, Vitonis, AF, Missmer, SA. Body size and endometriosis: Results from 20 years of follow-up within the Nurses’ Health Study II prospective cohort. Hum Reprod. 2013 Jul;28(7):1783–92.CrossRefGoogle ScholarPubMed Jia, SZ, Leng, JH, Shi, JH, Sun, PR, Lang, JH. Health-related quality of life in women with endometriosis: A systematic review. J Ovarian Res. 2012;5(1):29.CrossRefGoogle ScholarPubMed Young, K, Fisher, J, Kirkman, M. Women’s experiences of endometriosis: A systematic review and synthesis of qualitative research. J Fam Plann Reprod Health Care. 2015 Jul;41(3):225–34.CrossRefGoogle ScholarPubMed Wong, CL, Farquhar, C, Roberts, H, Proctor, M. Oral contraceptive pill for primary dysmenorrhoea. The Cochrane database of systematic reviews. 2009(4):Cd002120.Google Scholar Dunselman, GA, Vermeulen, N, Becker, C, et al. ESHRE guideline: Management of women with endometriosis. Hum Reprod. 2014 Mar;29(3):400–12.CrossRefGoogle ScholarPubMed Brueggmann, D, Templeman, C, Starzinski-Powitz, A, Rao, NP, Gayther, SA, Lawrenson, K. Novel three-dimensional in vitro models of ovarian endometriosis. J Ovarian Res. 2014;7:17.CrossRefGoogle ScholarPubMed Esfandiari, N, Nazemian, Z, Casper, RF. Three-dimensional culture of endometrial cells: an in vitro model of endometriosis. Am J Reprod Immunol. 2008 Oct;60(4):283–9.CrossRefGoogle Scholar Kobayashi, H, Imanaka, S, Nakamura, H, Tsuji, A. Understanding the role of epigenomic, genomic and genetic alterations in the development of endometriosis (review). Mol Med Rep. 2014 May;9(5):1483–505.CrossRefGoogle Scholar Becker, CM, Laufer, MR, Stratton, P, et al. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: I. Surgical phenotype data collection in endometriosis research. Fertil Steril. 2014 Nov;102(5):1213–22.CrossRefGoogle ScholarPubMed Fassbender, A, Rahmioglu, N, Vitonis, AF, et al. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: IV. Tissue collection, processing, and storage in endometriosis research. Fertil Steril. 2014 Nov;102(5):1244–53.CrossRefGoogle ScholarPubMed Vitonis, AF, Vincent, K, Rahmioglu, N, et al. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: II. Clinical and covariate phenotype data collection in endometriosis research. Fertil Steril. 2014 Nov;102(5):1223–32.CrossRefGoogle ScholarPubMed Commandeur, AE, Styer, AK, Teixeira, JM. Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth. Human reproduction update. 2015 Jul 3.CrossRefGoogle Scholar Mehine, M, Makinen, N, Heinonen, HR, Aaltonen, LA, Vahteristo, P. Genomics of uterine leiomyomas: insights from high-throughput sequencing. Fertil Steril. 2014 Sep;102(3):621–9.CrossRefGoogle ScholarPubMed Dutta, M, Subramani, E, Taunk, K, et al. Investigation of serum proteome alterations in human endometriosis. J Proteomics. 2015 Jan 30;114:182–96.Google Scholar Zhao, Y, Liu, YN, Li, Y, et al. Identification of biomarkers for endometriosis using clinical proteomics. Chin Med J (Engl). 2015 Feb 20;128(4):520–7.Google ScholarPubMed Calicchio, R, Doridot, L, Miralles, F, Mehats, C, Vaiman, D. DNA methylation, an epigenetic mode of gene expression regulation in reproductive science. Curr Pharm Des. 2014;20(11):1726–50.CrossRefGoogle ScholarPubMed Izawa, M, Taniguchi, F, Terakawa, N, Harada, T. Epigenetic aberration of gene expression in endometriosis. Front Biosci (Elite Ed). 2013;5:900–10.Google ScholarPubMed Kai, K, Nasu, K, Kawano, Y, et al. Death receptor 6 is epigenetically silenced by histone deacetylation in endometriosis and promotes the pathogenesis of endometriosis. Am J Reprod Immunol. 2013 Dec;70(6):485–96.CrossRefGoogle ScholarPubMed Monteiro, JB, Colon-Diaz, M, Garcia, M, et al. Endometriosis is characterized by a distinct pattern of histone 3 and histone 4 lysine modifications. Reprod Sci. 2014 Mar;21(3):305–18.CrossRefGoogle ScholarPubMed Nasu, K, Kawano, Y, Kai, K, et al. Aberrant histone modification in endometriosis. Front Biosci (Landmark Ed). 2014;19:1202–14.CrossRefGoogle ScholarPubMed Grummer, R. Animal models in endometriosis research. Human reproduction update. 2006 Sep–Oct;12(5):641–9.CrossRefGoogle ScholarPubMed Brown, J, Farquhar, C. Endometriosis: An overview of Cochrane Reviews. The Cochrane database of systematic reviews. 2014;3:Cd009590.Google Scholar Zhu, X, Hamilton, KD, McNicol, ED. Acupuncture for pain in endometriosis. The Cochrane database of systematic reviews. 2011(9):Cd007864.Google Scholar Davis, L, Kennedy, SS, Moore, J, Prentice, A. Modern combined oral contraceptives for pain associated with endometriosis. The Cochrane database of systematic reviews. 2007(3):Cd001019.Google Scholar Hughes, E, Brown, J, Collins, JJ, Farquhar, C, Fedorkow, DM, Vandekerckhove, P. Ovulation suppression for endometriosis. The Cochrane database of systematic reviews. 2007(3):Cd000155.Google Scholar Al Kadri, H, Hassan, S, Al-Fozan, HM, Hajeer, A. Hormone therapy for endometriosis and surgical menopause. The Cochrane database of systematic reviews. 2009(1):Cd005997.Google Scholar Abou-Setta, AM, Houston, B, Al-Inany, HG, Farquhar, C. Levonorgestrel-releasing intrauterine device (LNG-IUD) for symptomatic endometriosis following surgery. The Cochrane database of systematic reviews. 2013;1:Cd005072.Google Scholar Brown, J, Kives, S, Akhtar, M. Progestagens and anti-progestagens for pain associated with endometriosis. The Cochrane database of systematic reviews. 2012;3:Cd002122.Google Scholar Trefoux Bourdet, A, Luton, D, Koskas, M. Clinical utility of ulipristal acetate for the treatment of uterine fibroids: current evidence. International journal of women’s health. 2015;7:321–30.Google ScholarPubMed Kongnyuy, EJ, Wiysonge, CS. Interventions to reduce haemorrhage during myomectomy for fibroids. The Cochrane database of systematic reviews. 2014;8:Cd005355.Google Scholar Metwally, M, Cheong, YC, Horne, AW. Surgical treatment of fibroids for subfertility. The Cochrane database of systematic reviews. 2012;11:Cd003857.Google ScholarPubMed Ray, S, Ray, A. Non-surgical interventions for treating heavy menstrual bleeding (menorrhagia) in women with bleeding disorders. The Cochrane database of systematic reviews. 2014;11:Cd010338.Google Scholar Lethaby, A, Penninx, J, Hickey, M, Garry, R, Marjoribanks, J. Endometrial resection and ablation techniques for heavy menstrual bleeding. The Cochrane database of systematic reviews. 2013;8:Cd001501.Google Scholar Cheong, YC, Smotra, G, Williams, AC. Non-surgical interventions for the management of chronic pelvic pain. The Cochrane database of systematic reviews. 2014;3:Cd008797.Google Scholar Ahmad, G, Mackie, FL, Iles, DA, et al. Fluid and pharmacological agents for adhesion prevention after gynaecological surgery. The Cochrane database of systematic reviews. 2014;7:Cd001298.Google Scholar Accessibility compliance for the HTML of this chapter is currently unknown and may be updated in the future. To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle. Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply. Find out more about the Kindle Personal Document Service. - Research in Benign Gynaecology - - Book: Introduction to Research Methodology for Specialists and Trainees - Online publication: 04 August 2017 To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox. - Research in Benign Gynaecology - - Book: Introduction to Research Methodology for Specialists and Trainees - Online publication: 04 August 2017 To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive. - Research in Benign Gynaecology - - Book: Introduction to Research Methodology for Specialists and Trainees - Online publication: 04 August 2017

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (58)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
unpaywall
last seen: 2026-06-05T02:00:03.366016+00:00
License: CC0 · commercial use OK