Sexual Dysfunctions in Men and Women with Inflammatory Bowel Disease: The Influence of IBD-Related Clinical Factors and Depression on Sexual Function

Linda G.J. Bel, A. Vollebregt, Andrea E. van der Meulen‐de Jong, Herma H. Fidder, W. Rogier ten Hove, Cornelia W. Vliet-Vlieland, Moniek M. ter Kuile, Helena E. de Groot, Stephanie Both
In: The Journal of Sexual Medicine · 2015 · vol. 12(7) , pp. 1557–1567 · doi:10.1111/jsm.12913 · PMID:26054013 · W1536916101
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study found that active inflammatory bowel disease, fatigue, and depression negatively impact sexual function in both men and women with IBD, with depression mediating the relationship between disease activity and sexual dysfunction.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-19 · read from full text ⓘ

This study assessed sexual function in men and women with inflammatory bowel disease (IBD) and examined how IBD-related clinical factors and depression influenced sexual functioning. Using a clinical population (as reported by the authors) and statistical analyses incorporating disease-related variables and measures of depressive symptoms, the authors found that depression and certain IBD clinical factors were associated with sexual dysfunction patterns. A major caveat noted by the authors is that cross-sectional associations cannot establish causality. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

INTRODUCTION: Inflammatory bowel disease (IBD) is likely to have an impact on sexual function because of its symptoms, like diarrhea, fatigue, and abdominal pain. Depression is commonly reported in IBD and is also related to impaired sexual function. This study aimed to evaluate sexual function and its association with depression among patients with IBD compared with controls. METHODS: IBD patients registered at two hospitals participated. The control group consisted of a general practitioner practice population. The web-based questionnaire included the Female Sexual Function Index (FSFI) for women and the International Index of Erectile Function (IIEF) for men. Other variables evaluated were depression, disease activity, IBD-related quality of life, body image, and fatigue. RESULTS: In total, 168 female and 119 male patients were available for analysis (response rate 24%). Overall, patients with IBD did not significantly differ in prevalence of sexual dysfunctions from controls: female patients 52%, female controls 44%, male patients and male controls both 25%. However, men and women with an active disease scored significantly lower than patients in remission and controls, indicating impaired sexual functioning during disease activity. Significant associations were found between active disease, fatigue, depressive mood, quality of life, and sexual function for both male and female patients. The association between disease activity and sexual function was totally mediated by depression. CONCLUSION: Male and female IBD patients with an active disease show impaired sexual function relative to patients in remission and controls. Depression is the most important determinant for impaired sexual function in IBD.
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Persistent URL of this record https://hdl.handle.net/1887/117320 Documents - - Download - J_Sex_Med_2015_12_1557 - Not Applicable (or Unknown) - open access In Collections This item can be found in the following collections: Sexual Dysfunctions in Men and Women with Inflammatory Bowel Disease The Influence of IBD-Related Clinical Factors and Depression on Sexual Function - All authors - Bel, L.G.J.; Vollebregt, A.M.; Meulen-de Jong, A.E. van der; Fidder, H.H.; Hove, W.R. ten; Vliet-Vlieland, C.W.; Kuile, M.M. ter; Groot, H.E. de; Both, S. - Date - 2015-07-31 - Journal - The Journal of Sexual Medicine - Volume - 12 - Issue - 7 - Pages - 1557 - 1567

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