MACROGLOBULIN PROTEINS IN ADENOMYOSIS AND UTERINE LEIOMYOMA

The paper measured serum levels of alpha-2-macroglobulin (α2-MG), pregnancy-associated alpha-2-glycoprotein (ABG), and their IgG immune complexes in 25 healthy controls, 10 patients with uterine adenomyosis, groups with uterine leiomyoma with and without proliferation, and 17 patients with combined leiomyoma and adenomyosis. The strongest decrease in α2-MG concentration was observed in leiomyoma, with no decrease detected only in the combined leiomyoma–adenomyosis group, while ABG was elevated only in the combined condition and immune complexes (α2-MG–IgG and ABG–IgG) increased most strongly in patients with both diseases. Correlational relationships among the markers differed between normal and pathological states. A key limitation explicitly reflected by the abstract is the small, cross-sectional sample sizes across multiple subgroups, restricting interpretation of causal mechanisms. This paper is centrally about adenomyosis — it quantifies α2-MG/ABG and their IgG immune complexes in adenomyosis and in combination with uterine leiomyoma.

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