Association between endometriosis and increased arterial stiffness

Derya Kilic, Kilic D, Derya Kılıç, Tolga Güler, Tolga Guler, Guler T, Sevgican CI, Cihan Ilyas Sevgican, Cihan Kabukçu, Kabukcu C, Cihan Kabukcu, İpek Büber, Buber I, Ipek Buber, Mehmet Kilinc, Mehmet Kılınç, Kilinc M, Arslan M, Muhammet Arslan, Attar E, Erkut Attar, İsmail Doğu Kılıç, Ismail Dogu Kilic, Kilic ID
Kardiologia polska · 2020 · vol. 79(1) , pp. 58–65 · doi:10.33963/kp.15706 · PMID:33293502 · W3112988798
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

Women with endometriosis exhibit increased arterial stiffness as measured by cardio-ankle vascular index (CAVI) compared to controls, indicating a potential increased cardiovascular risk.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

The paper studied whether women with endometriosis have increased arterial stiffness by measuring cardio–ankle vascular index (CAVI) in 44 patients with endometriosis and 76 age-matched controls without endometriosis, with endometriosis diagnosed by histopathology or magnetic resonance imaging. The study found no group differences in age, body mass index, waist circumference, echocardiographic measures of cardiac structure/function, or systolic/diastolic blood pressure, but C-reactive protein was higher in the endometriosis group. Women with endometriosis had higher CAVI than controls, and this difference persisted after adjustment for age and left ventricular mass index. This paper is centrally about endometriosis — it specifically evaluates endometriosis association with increased arterial stiffness measured by CAVI.

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Abstract

BACKGROUND: Endometriosis is a common gynecologic disease associated with systemic inflammation and atherogenic risk factors. Therefore, women with endometriosis may have increased cardiovascular risk. AIMS: We aimed to evaluate arterial stiffness using cardio-ankle vascular index (CAVI) in women with and without endometriosis. METHODS: We enrolled 44 patients with endometriosis and 76 age‑matched controls without endometriosis.Endometriosis was diagnosed based on histopathologic examination or magnetic resonance imaging. Arterial stiffness was evaluated using CAVI in all study participants. RESULTS: No differences were observed between patients and controls in terms of age (median [interquartile range, IQR], 30 [24.25-5] years and 26 years [24-35] years, respectively), body mass index (median [IQR], 23.31 [20.82-24.98] kg/m2 and 23.74 [21.13-26.78] kg/m2, respectively), or waist circumference (median [IQR], 69 [64-75] cm and 72 [65-81.25] cm, respectively). C‑reactive protein levels were higher in women with endometriosis than in controls (median [IQR], 0.27 [0.14-0.68] mg/dl vs 0.12 [0.06-0.24] mg/dl; P <0.001). Left ventricular ejection fraction, left ventricular mass index (LVMI), relative wall thickness, as well as systolic and diastolic blood pressures were similar in both groups. Women with endometriosis had higher CAVI than controls (mean [SD], 5.961 [0.644] vs 5.554 [0.654]; P = 0.001). Elevated arterial stiffness was observed in the endometriosis group also after adjustment for age and LVMI. CONCLUSIONS: Our results indicate increased arterial stiffness measured by CAVI in women with endometriosis. Therefore,clinicians should be aware that these patients may be at increased cardiovascular risk.
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Abstract

Background: Endometriosis is a common gynecologic disease associated with systemic inflammation and atherogenic risk factors. Therefore, women with endometriosis may have increased cardiovascular risk. Aims: We aimed to evaluate arterial stiffness using cardio–ankle vascular index (CAVI) in women with and without endometriosis.

Methods

We enrolled 44 patients with endometriosis and 76 age‑matched controls without endometriosis.Endometriosis was diagnosed based on histopathologic examination or magnetic resonance imaging. Arterial stiffness was evaluated using CAVI in all study participants.

Results

No differences were observed between patients and controls in terms of age (median [interquartile range, IQR], 30 [24.25–5] years and 26 years [24–35] years, respectively), body mass index (median [IQR], 23.31 [20.82–24.98] kg/m2 and 23.74 [21.13–26.78] kg/m2, respectively), or waist circumference (median [IQR], 69 [64–75] cm and 72 [65–81.25] cm, respectively). C‑reactive protein levels were higher in women with endometriosis than in controls (median [IQR], 0.27 [0.14–0.68] mg/dl vs 0.12 [0.06–0.24] mg/dl; P < 0.001). Left ventricular ejection fraction, left ventricular mass index (LVMI), relative wall thickness, as well as systolic and diastolic blood pressures were similar in both groups. Women with endometriosis had higher CAVI than controls (mean [SD], 5.961 [0.644] vs 5.554 [0.654]; P = 0.001). Elevated arterial stiffness was observed in the endometriosis group also after adjustment for age and LVMI.

Conclusions

Our results indicate increased arterial stiffness measured by CAVI in women with endometriosis. Therefore,clinicians should be aware that these patients may be at increased cardiovascular risk.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Vascular Stiffness Adult Female Humans Stroke Volume Systole Ventricular Function, Left

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (23)

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