Anti-Müllerian hormone levels and spontaneous pregnancy in women undergoing surgery for benign ovarian cysts

Luisa Casadei, Francesca Dominici, Doriana Scaldaferri, Veronica Vicomandi, Susanna Ciacci, Emilio Piccione
In: Gynecological Endocrinology · 2018 · vol. 34(10) , pp. 909–912 · doi:10.1080/09513590.2018.1465548 · PMID:29724140 · W2800309348
article OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This study found that anti-Müllerian hormone levels decreased after benign ovarian cyst surgery, with significant recovery in endometrioma patients, but AMH did not predict spontaneous pregnancy rates.

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Abstract

This prospective study had the objective to compare anti-Müllerian hormone (AMH) serum levels among women with endometriomas and those with other benign ovarian cysts and verify a possible correlation between the AMH post-operative decline and the achievement of pregnancy. The study included 57 women undergoing laparoscopic surgery. Serum levels of AMH were measured preoperatively and at 6 and 12 months postoperatively. AMH serum levels decreased in both endometriomas and other benign cysts, but significant recovery was reported only in endometriomas (p = .029). Through an interview, information on reproductive outcome was obtained. The secondary endpoint was to identify other predictors of spontaneous pregnancy onset. After surgery 27 women attempted to conceive. At 18-months follow-up, 12 of them got pregnant, with a live birth of 37%. We did not record statistically significant differences in reproductive outcome between women with AMH serum levels lower and higher than 1.1 ng/ml (41.7 and 53.3% respectively). There was no statistically significant difference in AMH serum levels between pregnant and non-pregnant women, neither before nor after surgery. AMH did not appear to have a predictive role on reproductive outcome.

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