Endometriotic patient serum enhances endometrial stromal cell proliferation and viability: A preliminary study

Tetsuji Tanaka, Naohiko Umesaki
In: International Journal of Molecular Medicine · 2003 · doi:10.3892/ijmm.12.1.103 · W2012132333
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Serum from endometriotic patients significantly enhanced endometrial stromal cell proliferation and survival compared to serum from healthy women.

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This preliminary in vitro study tested how serum from eight women with endometriosis affects proliferation and viability of eutopic human endometrial stromal cells collected from three non-endometriotic women. All sera, including healthy control sera, stimulated stromal cell proliferation in a dose-dependent manner, but serum from the eight endometriotic patients significantly increased proliferation compared with healthy serum. In addition, five of eight endometriotic sera reduced cell death induced by 8-Br-cAMP, indicating antiapoptotic activity. The authors acknowledge the small sample size and report their findings as preliminary. This paper is centrally about endometriosis — it examines whether serum from endometriotic patients enhances eutopic endometrial stromal cell proliferation and survival in culture.

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Abstract

Decreased numbers of eutopic endometrial apoptotic cells have been reported in endometriotic patients, indicating the possibility of antiapoptotic effects of their sera. In this preliminary study, we examined the effects of serum from 8 endometriotic patients on cell proliferation and viability of eutopic human endometrial stromal cells obtained from 3 non-endometriotic women. Endometrial stromal cell proliferation was stimulated in a dose-dependent manner by all sera examined, including those of healthy women. Compared with the sera from healthy women, all sera from 8 endometriotic patients significantly enhanced stromal cell proliferation, and 5 of the 8 sera significantly inhibited 8-Br-cAMP-activation-induced cell death in endometrial stromal cells. Considering these results, we suggest that the stromal cell growth and surviving factor(s) from the serum of most endometriotic patients have a higher activity, which may stimulate ectopic implantation and proliferation of endometrial stromal cells.
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Print ISSN: 1107-3756 Online ISSN: 1791-244X International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease. International Journal of Oncology is an international journal devoted to oncology research and cancer treatment. Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery. Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine. Oncology Letters is an international journal devoted to Experimental and Clinical Oncology. Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology. International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis. Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology. Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition. Publishes open-access research on using epigenetics to advance understanding and treatment of human disease. An International Open Access Journal Devoted to General Medicine. Article - Authors: - Pages: 103-108|Published online on: July 1, 2003https://doi.org/10.3892/ijmm.12.1.103 - Expand metrics + Decreased numbers of eutopic endometrial apoptotic cells have been reported in endometriotic patients, indicating the possibility of antiapoptotic effects of their sera. In this preliminary study, we examined the effects of serum from 8 endometriotic patients on cell proliferation and viability of eutopic human endometrial stromal cells obtained from 3 non-endometriotic women. Endometrial stromal cell proliferation was stimulated in a dose-dependent manner by all sera examined, including those of healthy women. Compared with the sera from healthy women, all sera from 8 endometriotic patients significantly enhanced stromal cell proliferation, and 5 of the 8 sera significantly inhibited 8-Br-cAMP-activation-induced cell death in endometrial stromal cells. Considering these results, we suggest that the stromal cell growth and surviving factor(s) from the serum of most endometriotic patients have a higher activity, which may stimulate ectopic implantation and proliferation of endometrial stromal cells. Copy and paste a formatted citation Spandidos Publications style Tanaka T and Umesaki N: Endometriotic patient serum enhances endometrial stromal cell proliferation and viability: A preliminary study. Int J Mol Med 12: 103-108, 2003. APA Tanaka, T., & Umesaki, N. (2003). Endometriotic patient serum enhances endometrial stromal cell proliferation and viability: A preliminary study. International Journal of Molecular Medicine, 12, 103-108. https://doi.org/10.3892/ijmm.12.1.103 MLA Tanaka, T., Umesaki, N."Endometriotic patient serum enhances endometrial stromal cell proliferation and viability: A preliminary study". International Journal of Molecular Medicine 12.1 (2003): 103-108. Chicago Tanaka, T., Umesaki, N."Endometriotic patient serum enhances endometrial stromal cell proliferation and viability: A preliminary study". International Journal of Molecular Medicine 12, no. 1 (2003): 103-108. https://doi.org/10.3892/ijmm.12.1.103

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