{"paper_id":"4965030d-3e6c-4bac-87d6-a6f4d873bf79","body_text":"Print ISSN: 1107-3756\nOnline ISSN: 1791-244X\nInternational Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.\nInternational Journal of Oncology is an international journal devoted to oncology research and cancer treatment.\nCovers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.\nOncology Reports is an international journal devoted to fundamental and applied research in Oncology.\nExperimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.\nOncology Letters is an international journal devoted to Experimental and Clinical Oncology.\nExplores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.\nInternational journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.\nMultidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.\nOpen-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.\nPublishes open-access research on using epigenetics to advance understanding and treatment of human disease.\nAn International Open Access Journal Devoted to General Medicine.\nArticle\n- Authors:\n-\nPages: 103-108|Published online on: July 1, 2003https://doi.org/10.3892/ijmm.12.1.103\n- Expand metrics +\nDecreased numbers of eutopic endometrial apoptotic cells have been reported in endometriotic patients, indicating the possibility of antiapoptotic effects of their sera. In this preliminary study, we examined the effects of serum from 8 endometriotic patients on cell proliferation and viability of eutopic human endometrial stromal cells obtained from 3 non-endometriotic women. Endometrial stromal cell proliferation was stimulated in a dose-dependent manner by all sera examined, including those of healthy women. Compared with the sera from healthy women, all sera from 8 endometriotic patients significantly enhanced stromal cell proliferation, and 5 of the 8 sera significantly inhibited 8-Br-cAMP-activation-induced cell death in endometrial stromal cells. Considering these results, we suggest that the stromal cell growth and surviving factor(s) from the serum of most endometriotic patients have a higher activity, which may stimulate ectopic implantation and proliferation of endometrial stromal cells.\nCopy and paste a formatted citation\nSpandidos Publications style\nTanaka T and Umesaki N: Endometriotic patient serum enhances endometrial stromal cell proliferation and viability: A preliminary study. Int J Mol Med 12: 103-108, 2003.\nAPA\nTanaka, T., & Umesaki, N. (2003). Endometriotic patient serum enhances endometrial stromal cell proliferation and viability: A preliminary study. International Journal of Molecular Medicine, 12, 103-108. https://doi.org/10.3892/ijmm.12.1.103\nMLA\nTanaka, T., Umesaki, N.\"Endometriotic patient serum enhances endometrial stromal cell proliferation and viability: A preliminary study\". International Journal of Molecular Medicine 12.1 (2003): 103-108.\nChicago\nTanaka, T., Umesaki, N.\"Endometriotic patient serum enhances endometrial stromal cell proliferation and viability: A preliminary study\". International Journal of Molecular Medicine 12, no. 1 (2003): 103-108. https://doi.org/10.3892/ijmm.12.1.103","source_license":"CC0","license_restricted":false}