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This study assessed clinical and morphological characteristics of combined hyperplastic uterine diseases in 62 premenopausal women with chronic abnormal uterine bleeding, compared with 30 premenopausal controls undergoing preventive examination, using anthropometrics, ultrasound, metabolic evaluation (carbohydrate and lipid metabolism), and histology. The authors found that patients with uterine hyperplasia more often had lipid metabolism abnormalities (dyslipidemia) and carbohydrate metabolism disturbances associated with alimentary–constitutional obesity and metabolic syndrome, which were linked to a worse clinical course of the main disease. Histologically, the activity of adenomyosis foci correlated with the severity of clinical manifestations, including abnormal uterine bleeding and pain, and with coexisting lesions such as endometrial hyperplasia, chronic endometriosis, fibroids, and endometriosis. This paper is centrally about endometriosis and adenomyosis — it specifically examines how adenomyosis activity relates to combined uterine hyperplastic pathology.
Abstract
To determine clinical and morphological features of combined uterine hyperplastic diseases in premenopausal women at the background of adenomyosis, 62 patients operated on for chronic abnormal uterine bleeding were examined. The control group consisted of 30 premenopausal patients who applied for preventive examination. Anthropometric and ultrasound examinations, assessment of carbohydrate and lipid metabolism, histologic examination were done. It has been established that uterine hyperplasia patients often had lipid metabolism damages (dislipidemy) and damages of carbohydrate one (alimentary – constitutional obesity, metabolic syndrome) which worsen the clinical course of the main disease. According to histological examination data, the activity of adenomyosis foci in patients with comorbid uterine pathology correlated with the severity of clinical manifestations (abnormal uterine bleeding, pain) and the presence of comorbid lesions (concomitant endometrial hyperplasia, chronic endometriosis, fibroids, endometriosis).
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Clinical and morphological features of combined hyperplastic diseases of the uterus against the background of adenomyosis
DOI:
https://doi.org/10.12775/JEHS.2020.10.04.025Keywords
hyperplastic diseases of the uterus, adenomyosis, endometriosis, dislipidemy, metabolic syndromeAbstract
To determine clinical and morphological features of combined uterine hyperplastic diseases in premenopausal women at the background of adenomyosis, 62 patients operated on for chronic abnormal uterine bleeding were examined. The control group consisted of 30 premenopausal patients who applied for preventive examination. Anthropometric and ultrasound examinations, assessment of carbohydrate and lipid metabolism, histologic examination were done. It has been established that uterine hyperplasia patients often had lipid metabolism damages (dislipidemy) and damages of carbohydrate one (alimentary – constitutional obesity, metabolic syndrome) which worsen the clinical course of the main disease. According to histological examination data, the activity of adenomyosis foci in patients with comorbid uterine pathology correlated with the severity of clinical manifestations (abnormal uterine bleeding, pain) and the presence of comorbid lesions (concomitant endometrial hyperplasia, chronic endometriosis, fibroids, endometriosis).
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