{"paper_id":"4959b269-1bae-43b4-9e3a-b5c137665dbe","body_text":"Clinical and morphological features of combined hyperplastic diseases of the uterus against the background of adenomyosis\nDOI:\nhttps://doi.org/10.12775/JEHS.2020.10.04.025Keywords\nhyperplastic diseases of the uterus, adenomyosis, endometriosis, dislipidemy, metabolic syndromeAbstract\nTo determine clinical and morphological features of combined uterine hyperplastic diseases in premenopausal women at the background of adenomyosis, 62 patients operated on for chronic abnormal uterine bleeding were examined. The control group consisted of 30 premenopausal patients who applied for preventive examination. Anthropometric and ultrasound examinations, assessment of carbohydrate and lipid metabolism, histologic examination were done. It has been established that uterine hyperplasia patients often had lipid metabolism damages (dislipidemy) and damages of carbohydrate one (alimentary – constitutional obesity, metabolic syndrome) which worsen the clinical course of the main disease. According to histological examination data, the activity of adenomyosis foci in patients with comorbid uterine pathology correlated with the severity of clinical manifestations (abnormal uterine bleeding, pain) and the presence of comorbid lesions (concomitant endometrial hyperplasia, chronic endometriosis, fibroids, endometriosis).\nReferences\nNozari N. Screening and management of Metabolic Syndrome // Shiraz E-Medical Journal. 2011. Vol. 12. № 3. P. 144–149.\nSidorenko AV Morphological features of adenomyosis in women of reproductive age who have combined pathology of the uterus / AV Sidorenko.// Odessa Medical Journal. - 2018. - №2. - P. 44 - 49.\nGoncharenko G. Yu. Clinical and morphological analysis of genital endometriosis./ G. Yu. Goncharenko.// Achievements of biology and medicine. - 2016.– №1 (27). - P. 57 - 60.\nKunz G. Adenomyosis as a disorder of the early and late human reproductive period / G. Kunz, M. Herbertz, D. Beil // Reprod. Biomed. Online. - 2017. - Vol. 15. ¹6.-P. 681-685\nHamdan M. Influence of endometriosis on assisted reproductive technology outcomes: a systematic review and meta-analysis / M. Hamdan, S.Z. Omar, G. Dunselman // Obstet. Gynecol. - 2015. - Vol. 125. ¹ l.-P. 79-88.\nHealy D.L., Breheny S., Halliday J. et al. Prevalence and risk factors for obstetric haemorrhage in 6730 singleton births after assisted reproductive technology in Victoria Australia / D.L. Healy, S. Breheny, J. Halliday // Hum. Reprod.-2013.-Vol. 25. -¹ l.-P. 265- 274.\nUnified clinical protocol of primary, secondary (specialized) and tertiary (highly specialized) medical care. Tactics of management of patients with genital endometriosis. Approved by the Order of the Ministry of Health from 06.04.2016, №319 // Obstetrics. Gynecology. Genetics.-2016.-Vol.2, №2.-P.61-74.\nDamirov MM, Shabanov AM A new look at the pathogenesis of adenomyosis / MM Damirov.// Journal of NV Sklifosovsky Urgent medical care. - 2013. - №. 3.– P. 23 - 27\nKornatska AG Peculiarities of anatomical and functional state of pelvic organs and generative function in women with uterine leiomyoma / Kornatska AG, Kolesnichenko IS, Flaxemberg MA, Revenko OO // Women's health. - K., 2014. - № 10 (96). - P. 134–136\nYarotsky ME, Demyanenko LV, Doroga OP Peculiarities of benign uterine diseases in women of reproductive age with metabolic syndrome // Clinical Endocrinol and endocrine surgery.- 2016.- N 3.- C. 65-75\nAnfinogenova Ye. A. Active and inactive adenomiosis: comparative analysis in foci of ectopic endometrium (expression of aromatize p-450, receptors of estrogenes alfa and beta, receptors of progesterone) // Herald of education and development of Russian academy of natural sciences.- 20116.- N 20.- P. 74 -82\nDownloads\nPublished\nHow to Cite\nIssue\nSection\nLicense\nThe periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0\nStats\nNumber of views and downloads: 946\nNumber of citations: 0","source_license":"CC0","license_restricted":false}