Östradiolpflaster mit vierteljähriger oraler Gestagenzugabe in der Postmenopause

A. O. Mück, F. Schumacher, T. Rabe, F. U. Deuringer, B. Runnebaum
In: Archives of Gynecology and Obstetrics · 1993 · vol. 254(1-4) , pp. 300–302 · doi:10.1007/bf02266001 · W4233568884
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Therapeutic regimens using estradiol patches with quarterly oral progestogen are acceptable for late postmenopausal women under specific monitoring and precautions.

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The paper describes and concludes on a postmenopausal hormone regimen using an estradiol patch combined with oral gestagen added at quarterly (longer than monthly) intervals, emphasizing its use under specific precautions. It states that such sequential estrogen-gestagen schedules can be supported when restricted to women in late postmenopause, administered with an adequately high gestagen dose, monitored with regular vaginal sonography (particularly early, to determine timing for hormonally induced curettage), and paired with evaluation of intermenstrual bleeding. The authors additionally state that the importance of these therapy regimens remains high even over long-term conditions, without providing detailed study design or quantitative outcomes in the excerpt. Relevance to endometriosis: the paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Schlußfolgerung Bereits praktisch erprobte Therapieregime mit Zugabe von Gestagen in längeren als monatlichen Intervallen können unter Beobachtung bestimmter Vorsichtsmaßnahmen befürwortet werden: - 1. Nur Frauen in der späten Postmenopause. - 2. Ausreichendhohe Gestagendosis. - 3. Regelmäßige vaginalsonographische Kontrolle v.a. zu Beginn der Behandlung, um die Zeitpunkte der hormonellen Kurettage zu bestimmen und - 4. Abklärung von Zwischenblutungen. Die Akzentanz solcher Therapieschemata ist auch unter Langzeitbedingungen sehr hoch. Similar content being viewed by others Literatur Eicher, W., Mück, O.A.: Postmenopausale Symptome — Sequentielle Östrogen-Gestagen-Therapie erfolgreich. Therapiewoche 40, 52–56, 1990 Meuwissen, J.H., van Langen, H., Nielen, M.: Endometriumwachstum während kontinuierlicher, alleiniger Östrogensubstitutionstherapie mit Estraderm TTS (0,05 mg/die) bei 31 post-menopausalen Frauen Geburtsh. Frauenheilk. 52, 351–354, 1992 Mück, O.A., Lippert, T.H.: Fortschritte in der Therapie des Menopausalsyndroms — eine Standortbestimmung Medwelt 41, 1043–1047, 1990 Author information Authors and Affiliations Rights and permissions About this article Cite this article Mück, A.O., Schumacher, F., Rabe, T. et al. Östradiolpflaster mit vierteljähriger oraler Gestagenzugabe in der Postmenopause. Arch Gynecol Obstet 254, 300–302 (1993). https://doi.org/10.1007/BF02266001 Issue date: DOI: https://doi.org/10.1007/BF02266001

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