Combination GnRH antagonists for endometriosis: Balancing efficacy with side effects

L H R Whitaker, Lucy Whitaker, Saraswat L, L. Saraswat, Lucky Saraswat, Andrew W. Horne, Horne AW, A W Horne
Cell reports. Medicine · 2022 · vol. 3(9) , pp. 100748 · doi:10.1016/j.xcrm.2022.100748 · PMID:36130483 · PMC9512692 · W4296793390
Other OA: gold CC0 ⤵ 5 in-corpus citations
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This paper reviews trials of Relugolix, a combined hormone replacement therapy and GnRH antagonist, for treating endometriosis-associated pain.

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Abstract

Endometriosis is a chronic pain condition affecting 1 in 10 women. There is an unmet need for better medical treatments for endometriosis. We spotlight trials of a single preparation combined HRT-GnRH antagonist (Relugolix) by Giudice et al.,1 for endometriosis-associated pain.

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Outcome instruments

EHP-30 NRS-pain COS-Endo-2020

Condition tags

endometriosisdysmenorrheadyspareuniainfertility

MeSH descriptors

Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions Drug-Related Side Effects and Adverse Reactions

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (10)

Cited by (5)

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