Endometriomas with low-risk malignancy potential in ultrasonography with high human epididymis protein 4 and risk of ovarian malignancy algorithm: a cases series

Karacan T, Tolga Karacan, Eser Özyürek, Yesiralioglu S, Seyma Yesiralioglu, H. Asuman Kiyak, Taner Usta, Usta T, Engin Oral, Oral E
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2019 · vol. 36(2) , pp. 117–121 · doi:10.1080/09513590.2019.1653842 · PMID:31429337 · W2969875970
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This case series describes patients with "typical" endometrioma features on imaging who underwent surgery due to elevated HE4 and ROMA but were ultimately diagnosed with benign pathology.

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Abstract

Endometriosis is an estrogen-dependent disease that affects 5 to 15% of women of reproductive age. Data from large-cohort and case-control studies indicate an increased risk for ovarian cancers in women with endometrioma. Recently, as an ovarian cancer biomarker, human epididymal secretory protein E4 (HE4) has been increasingly investigated in the differentiating of endometrioma from ovary malignancy and in confirming the benign structure of the endometrioma. This case series study describes women who underwent surgery due to increased serum HE4 levels and higher Risk of Ovarian Malignancy Algorithm (ROMA) index, in whom the final pathology was reported as benign, although, ultrasonography and magnetic resonance imaging (MRI) findings showed features of "typical" endometrioma.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Ovarian Neoplasms WAP Four-Disulfide Core Domain Protein 2 Adult Adult Biomarkers, Tumor Biomarkers, Tumor Biomarkers, Tumor Case-Control Studies Case-Control Studies Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans Humans Ovarian Neoplasms Ovarian Neoplasms

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (18)

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