The mental health effects of hormonal and hormone-blocking treatments for endometriosis; A systematic review and narrative evidence synthesis

BackgroundEndometriosis affects 1 in 10 females and can cause debilitating pain and subfertility resulting in poor physical and mental health.Management includes surgery and hormonal manipulation (progestins/hormone blockers), many of those off-license.In our tertiary endometriosis centre many patients fear mental health side effects, or report suffering them with these treatments. AimWe aimed to assess the frequency and severity of mental health side effects from hormonal and hormoneblocking treatments and investigate whether mental health side effects have been adequately studied.