Global incidence and mortality of pancreatitis in women of childbearing age from 1990 to 2021.

Data on incidence and death were gathered from the GBD 2021 result tool ( http://ghdx.healthdata.org/gbd-results-tool ). The GBD 2021 provided global epidemiological data for 371 diseases from 1990 to 2021 33 . The data sources of the GBD study included household surveys, civil registrations, disease registries, disease notifications and other sources 33 . Each type of data was identified through systematic reviews of published studies, published reports, primary data sources such as health surveys, and datasets provided by GBD collaborators. The data extraction and estimation methods have been described in previous publications 33 , 34 . In this study, we selected data from 1990 to 2021 in five socio-demographic index (SDI) quintiles, 21 GBD regions and all countries/territories. The World Health Organization defines WCBA as women aged 15 to 49 years 35 . According to GBD 2021 Diseases and Injuries Collaborators, pancreatitis is defined as inflammation of the pancreas, including acute and chronic pancreatitis. Acute pancreatitis involves active inflammation and injury to the pancreas, resulting in severe upper abdominal pain and nausea, inappropriate release of pancreatic contents, and a systemic inflammatory response; chronic pancreatitis involves permanent damage to the pancreas from longstanding or recurrent inflammation. We used the 10th International Classification of Diseases code list to identify the disease and the code for acute pancreatitis is K85 and for chronic pancreatitis is K86 33 . The SDI is a composite indicator based on the geometric mean of total fertility (younger than 25 years), mean education (15 years and older), and lag-distributed income per capita 36 . The SDI values of all regions and countries/territories from 1990 to 2021 can be downloaded at: https://ghdx.healthdata.org/record/global-burden-disease-study-2021-gbd-2021-socio-demographic-index-sdi-1950–2021 . The indicators in GBD 2021 include mean estimates and 95% uncertainty intervals (UIs, the 2.5th and 97.5th percentiles among the 500 draws) 37 . All rates are reported per 100,000 persons. We calculated the estimated annual percentage changes (EAPCs) to assess the temporal trends of the incidence and death rates. If the EAPC and its lower 95% confidence interval (CI) boundary were both greater than zero, an increasing trend was deemed. If the EAPC and its upper 95% CI boundary were both lower than zero, a decreasing trend was deemed 38 . Total percentage change was used to represent the number change from 1990 to 2021. Data statistical analyses and visualization were performed in R software (version 4.2.2).

Globally, the incident cases of pancreatitis among women aged 15 to 49 years increased by 43.8% (95% UI: 39% to 49%) between 1990 and 2021, from 351,302 (276,609 to 448,102) to 505,012 (409,536 to 627,684) (Fig.  1 ). The incidence rate of pancreatitis among this age group decreased by 1.4%, from 26.3 per 100,000 people in 1990 to 25.9 per 100,000 people in 2021, with an EAPC of -0.15 (-0.21 to -0.09) (Table  1 ). In 2021, the number of deaths in WCBA was 7,002 (5,647 to 8,857), a 31.9% (8.9% to 58%) increase from 1990. The global death rate of pancreatitis in WCBA decreased by 9.5%, from 0.39 per 100,000 in 1990 to 0.36 per 100,000 in 2021, with an EAPC of -0.42 (-0.58 to -0.26). Fig. 1 The counts and rates (per 100,000 people) of incidence and death of pancreatitis in women of childbearing age from 1990 to 2021. Each line represents a different SDI quintile. SDI socio-demographic index. The counts and rates (per 100,000 people) of incidence and death of pancreatitis in women of childbearing age from 1990 to 2021. Each line represents a different SDI quintile. SDI socio-demographic index. Table 1 Incidence and death rate in 2021 and their EAPCs from 1990 to 2021 of pancreatitis in WCBA in different age subgroups and five SDI quintiles. Incidence rate in 2021 (per 100,000) EAPC of incidence rate Death rate in 2021 (per 100,000) EAPC of death rate Global 15 to 49 25.9 (21 to 32.2) −0.15 (−0.21 to −0.09) 0.36 (0.29 to 0.45) −0.42 (−0.58 to −0.26) 15 to 19 13.8 (8.7 to 20) 0.45 (0.42 to 0.48) 0.1 (0.07 to 0.14) −0.92 (−1.09 to −0.75) 20 to 24 17.8 (11.7 to 25.9) 0.26 (0.22 to 0.31) 0.16 (0.11 to 0.21) −0.81 (−1.02 to −0.6) 25 to 29 21.8 (14.5 to 31.9) −0.06 (−0.12 to 0) 0.21 (0.16 to 0.28) −0.63 (−0.88 to −0.38) 30 to 34 26.6 (15.8 to 39.7) −0.33 (−0.45 to −0.2) 0.29 (0.23 to 0.37) −0.69 (−0.91 to −0.46) 35 to 39 31.2 (20.2 to 45.9) −0.55 (−0.71 to −0.4) 0.42 (0.35 to 0.53) −0.78 (−0.89 to −0.67) 40 to 44 34.9 (24.1 to 50.3) −0.78 (−0.89 to −0.67) 0.57 (0.47 to 0.74) −1.08 (−1.22 to −0.93) 45 to 49 40.2 (27.7 to 55.6) −0.78 (−0.86 to −0.69) 0.93 (0.68 to 1.18) −0.73 (−0.92 to −0.54) SDI quintiles High SDI 33.1 (29.3 to 38.2) −0.64 (−0.76 to −0.52) 0.23 (0.22 to 0.25) −1.02 (−1.23 to −0.8) High-middle SDI 31.9 (26.1 to 39.8) −0.22 (−0.3 to −0.15) 0.56 (0.5 to 0.62) 0.04 (−0.32 to 0.4) Middle SDI 23.4 (18.6 to 29.7) 0.22 (0.1 to 0.34) 0.3 (0.24 to 0.37) −0.48 (−0.59 to −0.36) Low-middle SDI 24.9 (19 to 31.9) 0.47 (0.43 to 0.52) 0.43 (0.29 to 0.63) −0.29 (−0.46 to −0.13) Low SDI 20.5 (15.7 to 26.4) 0.18 (0.17 to 0.19) 0.27 (0.16 to 0.38) −1.05 (−1.18 to −0.92) WCBA women of childbearing age, SDI socio-demographic index, EAPC estimated annual percentage change. Incidence and death rate in 2021 and their EAPCs from 1990 to 2021 of pancreatitis in WCBA in different age subgroups and five SDI quintiles. WCBA women of childbearing age, SDI socio-demographic index, EAPC estimated annual percentage change. Globally, from 1990 to 2021, the incident cases of pancreatitis at least increased by 29% in every age subgroup in WCBA (15 to 19 years: from 30,751 to 41,803; 20 to 24 years: from 39,289 to 52,168; 25 to 29: years: from 49,080 to 63,403; 30 to 34 years: from 56,708 to 79,555; 35 to 39 years: from 62,476 to 86,773; 40 to 44 years: 58,045 to 86,536) and even increased nearly 70% for females aged 45 to 49 years (from 54,952 to 94,774). The different age groups exhibited different pancreatitis change pattern from 1990 to 2021 (Figure S1 ). Pancreatitis incidence rate across 25 to 49 years decreased at a noticeable rate during 1990 to 2021, especially among those aged 40 to 44 years (EAPC=-0.78, -0.89 to -0.67). Females aged 15 to 24 years showed upward trends, with a greater increase in people aged 15 to 19 years (EAPC = 0.45, 0.42 to 0.48). The death rate of pancreatitis decreased across all age subgroups in WCBA worldwide, especially among females aged 40 to 44 years (EAPC= -1.08, -1.22 to -0.93). In 2021, the global incidence and death rates for pancreatitis per 100,000 in WCBA increased with age, with the highest incidence (40.2, 27.7 to 55.6) and death (0.92, 0.68 to 1.2) rates in 45 to 49 years age group (Fig.  2 ). Moreover, people over 35 years old accounted for more than 50% of the incident cases and deaths (Figure S2 ). Fig. 2 The age-specific incidence and death rates (per 100,000 people) of pancreatitis in women of childbearing age in 2021. Each line represents a different SDI quintile. SDI socio-demographic index. The age-specific incidence and death rates (per 100,000 people) of pancreatitis in women of childbearing age in 2021. Each line represents a different SDI quintile. SDI socio-demographic index. From 1990 to 2021, four of the 21 GBD regions showed decreasing trends in incident cases, and five of the 21 regions showed decreasing trends in the number of deaths of pancreatitis in WCBA (Figure S3). The largest increases in incidence and death rates of pancreatitis in WCBA were in South Asia and Eastern Europe, respectively, with EAPCs of 0.6 (0.52 to 0.68) and 2.12 (1.49 to 2.76), respectively. The greatest reductions in incidence and death rate of pancreatitis in WCBA were observed in high-income North America and high-income Asia Pacific, with EAPCs of -0.98 (-1.15 to -0.81) and  -2.23 (-2.38 to -2.07), respectively (Table  2 ). Table 2 Incidence and death rate in 2021 and their EAPCs from 1990 to 2021 of pancreatitis in WCBA in 21 GBD regions. Location Incidence rate in 2021 (per 100,000) EAPC of incidence rate Death rate in 2021 (per 100,000) EAPC of death rate Andean Latin America 41.6 (34.7 to 51.3) −0.11 (−0.17 to −0.05) 0.67 (0.48 to 0.92) −2.11 (−2.27 to −1.94) Australasia 32 (24.9 to 42) −0.09 (−0.12 to −0.05) 0.12 (0.1 to 0.13) −0.5 (−0.69 to −0.32) Caribbean 24.7 (19 to 32.2) 0.16 (0.14 to 0.18) 0.37 (0.27 to 0.54) −0.04 (−0.15 to 0.07) Central Asia 37.1 (29.6 to 47.5) 0.35 (0.3 to 0.39) 0.53 (0.44 to 0.64) −0.84 (−1.26 to −0.42) Central Europe 27.9 (24.7 to 32.1) −0.66 (−0.81 to −0.52) 0.57 (0.51 to 0.64) −1.7 (−1.89 to −1.51) Central Latin America 33.6 (27.3 to 41.4) 0.58 (0.52 to 0.64) 0.68 (0.57 to 0.79) 0.32 (0.05 to 0.59) Central Sub-Saharan Africa 16.9 (12.6 to 22) 0.03 (0 to 0.06) 0.07 (0.04 to 0.13) 0.23 (0.12 to 0.35) East Asia 16.9 (13.2 to 22.2) −0.94 (−1.3 to −0.58) 0.16 (0.1 to 0.23) −2.05 (−2.17 to −1.93) Eastern Europe 86.4 (66.3 to 114.2) 0.51 (0.31 to 0.7) 2.4 (2.1 to 2.7) 2.12 (1.49 to 2.76) Eastern Sub-Saharan Africa 17.9 (13.6 to 23.2) 0.13 (0.09 to 0.17) 0.08 (0.04 to 0.13) 0.16 (0.13 to 0.19) High-income Asia Pacific 17.9 (14.7 to 22) −0.27 (−0.35 to −0.2) 0.08 (0.07 to 0.09) −2.23 (−2.38 to −2.07) High-income North America 50.4 (45.2 to 56.2) −0.98 (−1.15 to −0.81) 0.31 (0.3 to 0.33) −0.06 (−0.43 to 0.3) North Africa and Middle East 19.8 (15.7 to 25.3) 0.3 (0.25 to 0.35) 0.11 (0.07 to 0.16) −0.38 (−0.48 to −0.29) Oceania 14.5 (11 to 19.1) 0.07 (0.06 to 0.09) 0.13 (0.06 to 0.21) −1.6 (−1.87 to −1.33) South Asia 28.6 (21.7 to 36.5) 0.6 (0.52 to 0.68) 0.47 (0.29 to 0.73) −0.58 (−0.8 to −0.36) Southeast Asia 21.5 (16.9 to 27.9) 0.34 (0.33 to 0.35) 0.17 (0.13 to 0.33) −1.18 (−1.33 to −1.04) Southern Latin America 46.6 (38.3 to 57.5) 0.27 (0.1 to 0.44) 0.5 (0.46 to 0.54) −1.44 (−1.84 to −1.03) Southern Sub-Saharan Africa 21.8 (16.8 to 28.9) 0.14 (0.09 to 0.18) 0.14 (0.08 to 0.19) 0.74 (0.18 to 1.3) Tropical Latin America 11.6 (9.7 to 14.3) 0.58 (0.51 to 0.65) 0.76 (0.71 to 0.82) 0.88 (0.68 to 1.07) Western Europe 25.6 (22.8 to 29.2) 0.26 (0.12 to 0.4) 0.18 (0.17 to 0.18) −1.36 (−1.56 to −1.17) Western Sub-Saharan Africa 21.4 (16.3 to 27.6) 0.16 (0.15 to 0.18) 0.37 (0.17 to 0.51) 0.44 (0.36 to 0.52) WCBA women of childbearing age, GBD global burden of disease, EAPC estimated annual percentage change. Incidence and death rate in 2021 and their EAPCs from 1990 to 2021 of pancreatitis in WCBA in 21 GBD regions. WCBA women of childbearing age, GBD global burden of disease, EAPC estimated annual percentage change. In 2021, among 21 GBD regions, the highest incidence rates of pancreatitis in WCBA were in Eastern Europe (86.4), high-income North America (50.4) and Southern Latin America (46.6). The highest regional incidence rate (86.4 in Eastern Europe) was 7.4 times higher than the lowest (11.6 in Tropical Latin America). Eastern Europe (2.4) also had the highest death rate from pancreatitis in WCBA in 2021. At the national level, Chile had the highest increase in the incidence of pancreatitis in WCBA from 1990 to 2021, with an EAPC of 1.4 (1.16 to 1.65), followed by Singapore (EAPC = 1.13, 1.01 to 1.24) and Mexico (EAPC = 1.1, 1 to 1.21) (Table S1 ). In the same period, Singapore showed the most substantial decrease in the death rate of pancreatitis in the WCBA, with an EAPC of -4.37 (-4.7 to -4.03). In 2021, four countries, including India, China, the United States and Russia, reported more than 30,000 incident cases of pancreatitis in WCBA. Fifty-eight countries/territories had at least the global average incidence rate in 2021, of which the highest incidence rates were observed in Russian Federation, Ukraine and Republic of Moldova. The highest death rates were also observed in these three countries (Fig.  3 ). Fig. 3 The incidence and death rates (per 100,000 people) of pancreatitis in women of childbearing age in all countries/territories in 2021. The incidence and death rates (per 100,000 people) of pancreatitis in women of childbearing age in all countries/territories in 2021. From 1990 to 2021, the number of incident cases and deaths showed a basically unchanged or slightly decreasing trend in the high-SDI quintile, whereas the number of incident cases has more than doubled and the number of deaths increased by more than 60% in low-middle- and low-SDI quintiles. Incidence rates in the high- and high-middle-SDI quintiles showed downward trends, with EAPCs of -0.64 (-0.76 to -0.52) and -0.22 (-0.3 to -0.15), respectively. Except for the high-middle-SDI quintile, other four SDI quintiles showed downward trends in the death rate (Fig.  1 ). Countries with different SDI quintiles showed different epidemiological patterns. Among the five SDI quintiles, the incidence rates ranged from 20.5 (15.7 to 26.4) to 33.1 (29.3 to 38.2) in 2021, with countries in the high-SDI quintile having the highest incidence rate and countries in the low-SDI quintile having the lowest. The death rates ranged from 0.23 (0.22 to 0.25) in the high-SDI quintile to 0.56 (0.5 to 0.62) in the high-middle SDI quintile. To understand the burden of pancreatitis in WCBA in relation to countries’ sociodemographic status, we examined the relationships between the incidence and death rates (in 2021) and the SDI (in 2021) (Fig.  4 ). The results revealed a positive correlation, in that countries with high SDI had relatively high incidence rate, whereas countries with low SDI had much lower incidence rate. The correlation curve of the death rate and SDI showed a smooth straight line. We found that some high-income countries, Estonia, Canada and Latvia, are well located in above the fitted curve, while some high-SDI countries are located below the fitted curve, including Singapore and Netherlands. The relationships between incidence and death rates (from 1990 to 2021) and the SDI (in 2021) across 21 GBD regions are shown in Figure S4. Fig. 4 The relationships between incidence and death rates (per 100,000 people, in 2021) of pancreatitis in women of childbearing age and SDI (in 2021) in all countries/territories. Each dot represents a country or territory. SDI socio-demographic index. The relationships between incidence and death rates (per 100,000 people, in 2021) of pancreatitis in women of childbearing age and SDI (in 2021) in all countries/territories. Each dot represents a country or territory. SDI socio-demographic index.

In this study, we explored the trends in the global incidence and death of pancreatitis in the WCBA from 1990 to 2021. The global incidence and death rates of pancreatitis in WCBA showed downward trends, but they still remain high in high- and high-middle-SDI regions. In consideration of the impact of pancreatitis on WCBA, more attention should be given to the burden of pancreatitis in this group in the future. Globally, the pancreatitis is still a serious medical problem. Pregnancy is important for adult women, and severe pregnancy complications caused by gestational pancreatitis affect the quality of life and survival of mothers and children. Compared with general pregnant women, women with pancreatitis need to consider many clinical factors, including the effects of drug use on the fetus, the timing of surgical intervention, and the prevention of complications of severe pancreatitis. The occurrence of acute pancreatitis in women may be related to gallstones and cholestasis. Significantly elevated levels of estrogen and progesterone during pregnancy increase cholesterol levels and promote cholestasis 10 . Hypertriglyceridemia is another well-known etiology of acute pancreatitis. In the third trimester of pregnancy, the levels of triglyceride are approximately 2 to 4 times greater than normal value 10 . The global age-standardized mean body-mass index increased from 22.1 kg/m 2 in 1975 to 24.4 kg/m 2 in 2014 in women, and nearly 5.0% of the world’s women were severely obese 11 . By 2050, more than 1.31 billion people are projected to have diabetes 12 . Given the increases in the prevalence of diabetes, metabolic syndrome, and obesity, we should pay attention to hypertriglyceridemia-induced pancreatitis in females. Pancreatitis has recently been observed much more frequently incidentally during pregnancy. In a 10-year retrospective study, acute pancreatitis occurred during pregnancy in 33.0 per 100,000 people 13 . Hospitalization data for women showed that the prevalence of acute pancreatitis was 20.02 per 100,000 people during pregnancy 14 . Acute pancreatitis also threatens the lives of women and newborns. The maternal and fetal mortality rates are as high as 3.3% and 11.6%, respectively, for acute pancreatitis during pregnancy 15 . Research has indicated that lactate dehydrogenase, triglyceride, cholesterol, and albumin levels are independent predictors of severe acute pancreatitis during pregnancy 16 . As the increased risks of maternal and fetal death are significantly correlated with the severity of acute pancreatitis during pregnancy, more prevention measures and effective methods to predict prognosis are necessary in the future. The higher incidence rate in the high-SDI quintile may be attributed to the use of advanced and complete diagnostic tools. The development of computed tomography and magnetic resonance imaging has improved the detection rate of pancreatitis 17 , 18 . At the regional level, Europe had high incidence rates for pancreatitis in WCBA. The incidence of acute pancreatitis continues to increase in most parts of Europe 19 . It was reported that the incidence ranged from 5.6 per 100,000 people in Albania, to 100.0 per 100,000 in the Poland 19 . Alcohol use and gallstone diseases are the most common etiologies of pancreatitis in Eastern Europe. Per capita alcohol consumption increased from the 1970s to the 1990s in many European countries 19 . In 2020, more than 50% of females aged 15 to 39 years in Eastern Europe were consuming in excess of the non-drinker equivalence 20 . It was also reported that the age-standardized incidence rate of pancreatitis was much higher in females than in males in Eastern Europe 21 . We noticed that females aged 15 to 24 years showed increase trends in incidence of pancreatitis. Among the population aged 15 to 49 years, alcohol use is the leading global risk factor for risk-attributable disease burden, causing 2.3% disability adjusted of life years for females 22 . In view of the harm of alcohol overuse, health education for adolescents and young adults should be developed in the future. Cholelithiasis is also a common cause of acute pancreatitis 1 . According to GBD 2019, the incidence and prevalence of gallbladder and biliary diseases was much higher in Europe and America 23 , 24 . The prevalence of gallstones ranges from 11% to 35% in America adults and from 5.9% to 21.9% in Europe 25 , 26 . However, it was reported that Asia (5.1%) had lower prevalence of gallstones 27 . The worldwide decline in the pancreatitis death rate may be due to advances in medical care. Currently, the treatment of pancreatitis mainly includes intravenous fluid resuscitation, analgesia, enteral nutrition and organ support 28 . Recently, great progress has been made in the etiology, diagnosis, and treatment of complications of pancreatitis 29 . With the progress of clinical nutrition, critical care medicine and endoscopic technology, the treatment of pancreatitis is moving toward standardization. The extensive application of multidisciplinary team model is also an inevitable trend in the standardized treatment of pancreatitis. To reduce the burden of pancreatitis in women in the future, we should pay attention to this disease in WCBA. Prevention of acute pancreatitis requires concerted contributions from health care professionals from different disciplines, including primary care physicians, gastroenterologists, surgeons, radiologists, endocrinologists, dietitians, and public health experts 30 . Depending on the cause, preventive interventions include cholecystectomy for biliary pancreatitis, a reduction in alcohol use for alcoholic pancreatitis, strict control of blood lipids for hypertriglyceridemia-induced pancreatitis, and a reduction in the risk factors associated with post-ERCP pancreatitis. As obesity is a risk factor for new gallstones during pregnancy, the first recommendation is to pay attention to diet and weight to prevent the formation of new gallbladder diseases. Additionally, the increase in the serum triglyceride level during pregnancy should be screened for, and the diet should be modified if necessary. Moreover, health education among women is also necessary, especially for biliary and pancreatic health. As we observed an increasing incidence of pancreatitis in females aged 15 to 24, we should also focus on alcohol consumption among young females. Severe acute pancreatitis and chronic pancreatitis patients need multidisciplinary management. The important factors to reduced complications and mortality include fluid resuscitation, nutritional support and analgesia. For instance, early enteral nutrition may reduce mortality in patients with moderate or severe acute pancreatitis 31 . Moreover, a multicenter retrospective study found that epidural analgesia in acute pancreatitis patients admitted to the intensive care unit was associated with lower 30-day mortality 32 . More prospective studies evaluating acute pancreatitis mortality are needed in the future. This study had several limitations. First, incomplete or developing disease registries in low-income countries can lead us to underestimate the incidence of pancreatitis. The GBD study used statistical modeling methods, especially at the national level, and the data in the GBD study relied on modeling data due to the lack of raw data. Next, pancreatitis included in the GBD database was not classified by disease type, such as acute pancreatitis, chronic pancreatitis, or autoimmune pancreatitis, which may limit our broad exploration. Additionally, we should note the hysteresis property of GBD data. Future work should pay attention to more raw epidemiological data on pancreatitis in WCBA, especially in low-middle and low-income countries. The economic burden caused by pancreatitis should also be further studied. Overall, the global pancreatitis incidence and death in WCBA has decreased since 1990, but the incidence is still high in some high-SDI-countries. Significant increase in pancreatitis incidence occurred in females aged 15 to 24 years. We should pay attention to risk factors for pancreatitis in WCBA, including alcohol use, gallstones, and hypertriglyceridemia. More efficient public health measures are needed to reduce the burden of pancreatitis.

Pancreatitis is an inflammatory disorder of the pancreas, and the incidence of pancreatitis continues to increase worldwide 1 . Acute pancreatitis can progress to severe acute pancreatitis, with a higher mortality rate, and may also lead to chronic pancreatitis. Currently, pancreatitis is a serious health problem in East Asia, the United States and European countries 2 – 5 . With increasing risk factors such as cholelithiasis, hyperlipidemia, and alcohol consumption, the prevalence of pancreatitis may continue to increase. Women are prone to cholelithiasis, and hormonal changes in women during pregnancy cause an increase in cholesterol, which can easily lead to the formation of gallstones. It is estimated that 12% of women will experience cholelithiasis during pregnancy, and up to 70% of reported pancreatitis cases are attributed to gallstone disease 6 . Moreover, hypertriglyceridemia is a known etiology of pancreatitis. During the third trimester of pregnancy, triglyceride levels can increase two to fourfold 7 . The aim of Sustainable Development Goal 3.1 is to reduce the global maternal mortality ratio to less than 70 per 100,000 live births by 2030 8 . Therefore, it is highly significant to fully assess the epidemiology of pancreatitis in women of childbearing age (WCBA). However, studies on the epidemiology of pancreatitis in WCBA have been conducted only in limited regions or countries. Assessing the incidence and mortality of pancreatitis and analyzing its change trends in WCBA will help to better understand the epidemiology of pancreatitis and promote women’s health. The Global Buden of Disease (GBD) Study provides useful data for epidemiological research 9 . In this study, we conducted a systematic analysis based on GBD 2021 to assess the global, regional and national temporal trends in the incidence and death of pancreatitis in the WCBA from 1990 to 2021.

Below is the link to the electronic supplementary material. Supplementary Material 1 Supplementary Material 1 Supplementary Material 2 Supplementary Material 2