Progress with oocyte cryopreservation

Eleonora Porcu, Porcu E, Stefano Venturoli, Venturoli S
Current opinion in obstetrics & gynecology · 2006 · doi:10.1097/01.gco.0000193015.96275.2d · PMID:16735826
review OA: closed public-domain-us
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⚙ AI-generated summary by qwen3.7-flash, 2026-09-06 ⓘ

This review examines oocyte cryopreservation, highlighting its potential to replace embryo freezing and serve as a fertility preservation alternative for women with endometriosis or undergoing ovarian surgery.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-06 · read from full text ⓘ

This review examines the current state and clinical applications of human oocyte cryopreservation, highlighting recent advancements in overcoming temperature and cryoprotectant-induced cellular damage. The authors note that improved technical modifications have significantly enhanced clinical efficiency, resulting in healthy births and supporting the procedure as a viable alternative to embryo freezing for preserving reproductive flexibility. Key indications include protecting fertility in women facing antineoplastic treatments, genetic premature ovarian failure, or those undergoing ovarian surgery. Relevance to endometriosis: listed as one indication for oocyte cryopreservation, specifically regarding patients who may require ovarian surgery related to the condition.

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Abstract

PURPOSE OF REVIEW: This article reviews human oocyte cryopreservation, one of the most stimulating challenges of assisted reproduction technology. Since the first steps in assisted reproduction technology, researchers have pursued this goal, to greatly improve the management of infertility treatments. This present review depicts the present state of research and clinical applications of this methodology. RECENT FINDINGS: Recent literature focuses on the possible mechanisms of oocyte damage caused by temperature and cryoprotectant injury and forecasts possible technological solutions. Several papers illustrate encouraging results in the increasing clinical application of this procedure. SUMMARY: Findings give support to several indications of human female gamete cryostorage. Oocyte cryopreservation might replace embryo freezing. Egg freezing offers an alternative to women at risk of losing their reproductive function, caused by antineoplastic treatments, endometriosis, ovarian surgery or genetic premature ovarian failure. In addition, oocyte storage may contribute to an increase in in-vitro fertilization flexibility. Despite the early disappointing results, recent technical modifications have improved the clinical efficiency greatly, with the birth of several healthy children.
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Progress with oocyte cryopreservation - Eleonora Porcu - Stefano Venturoli Purpose of review This article reviews human oocyte cryopreservation, one of the most stimulating challenges of assisted reproduction technology. Since the first steps in assisted reproduction technology, researchers have pursued this goal, to greatly improve the management of infertility treatments. This present review depicts the present state of research and clinical applications of this methodology. Recent findings Recent literature focuses on the possible mechanisms of oocyte damage caused by temperature and cryoprotectant injury and forecasts possible technological solutions. Several papers illustrate encouraging results in the increasing clinical application of this procedure. Summary Findings give support to several indications of human female gamete cryostorage. Oocyte cryopreservation might replace embryo freezing. Egg freezing offers an alternative to women at risk of losing their reproductive function, caused by antineoplastic treatments, endometriosis, ovarian surgery or genetic premature ovarian failure. In addition, oocyte storage may contribute to an increase in in-vitro fertilization flexibility. Despite the early disappointing results, recent technical modifications have improved the clinical efficiency greatly, with the birth of several healthy children.

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Condition tags

endometriosisinfertility

MeSH descriptors

Cryopreservation Oocytes Reproductive Techniques, Assisted Cell Survival Cryopreservation Female Fertilization Humans Pregnancy Sperm Injections, Intracytoplasmic

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europepmc
last seen: 2026-09-21T06:08:07.822426+00:00
pubmed
last seen: 2026-05-13T22:15:18.313808+00:00
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