Association of miR-146a and miR196a2 genotype with susceptibility to idiopathic recurrent pregnancy loss in Iranian women: A case-control study

Emad Babakhanzadeh, Babakhanzadeh E, Hamid Danaei, Danaei H, Mohammad Abedinzadeh, Abedinzadeh M, Ashrafzadeh HR, Hamid Reza Ashrafzadeh, Ghasemi N, Nasrin Ghasemi
International journal of reproductive biomedicine · 2021 · vol. 19(8) , pp. 725–732 · doi:10.18502/ijrm.v19i8.9620 · PMID:34568733 · PMC8458919
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This case-control study found no statistically significant association between miR-146aC > G and miR-196a2T > C genotypes and susceptibility to idiopathic recurrent pregnancy loss in Iranian women.

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This case-control study investigated the association between single nucleotide polymorphisms in miR-146a (rs2910164) and miR-196a2 (rs11614913) and susceptibility to idiopathic recurrent pregnancy loss among 214 Iranian women compared to 147 controls. Genotyping was performed using PCR-restriction fragment length polymorphism analysis, revealing no statistically significant differences in allele or genotype frequencies for either polymorphism between the patient and control groups. The authors note that while previous studies in other ethnicities have shown conflicting results, their findings align with some prior research indicating no direct link, suggesting that ethnic variations may influence these genetic associations. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

BACKGROUND: Recurrent pregnancy loss (RPL) is the most common complaint of pregnancy in females with a prevalence of 5%. Numerous documents have shown that single nucleotide polymorphisms are able to change miRNA transcription and/or maturation, which may alter the incidence of disorders such as RPL. OBJECTIVE: To assess the relationship of miR-146aC > G (rs2910164) and miR-196a2T > C (rs11614913) with RPL susceptibility in Iranian women. MATERIALS AND METHODS: Blood samples were collected from 214 women who had experienced at least two consecutive spontaneous miscarriages (case) and 147 normal individuals without a history of miscarriage (control). MiR-146aC > G and miR-196a2T > C genotypes were evaluated via the restriction fragment length polymorphism technique. RESULTS: The genotypes incidence did not show a significant difference in pre-miR-146aC > G polymorphism CC vs CG + GG (p = 0.854; OR = 0.933; 95% CI) and CC + CG vs GG (p = 0.282; OR = 1.454; 95% CI). Also, no significant difference was observed between pre-miR-196a2T > C polymorphism TT vs TC + CC (p = 0.862; OR = 0.938; 95% CI) and TT + TC vs CC and (p = 0.291; OR = 1.462; 95% CI) in both the case and control groups. CONCLUSION: The results showed that although the distribution of miR-146aC > G and miR-196a2T > C was different between the unknown RPL and control groups, these variances were not statistically significant.
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Considering the aforementioned points, the miR-146a and miR-196a2 targets are associated with cell proliferation and development. Although the distribution of miR-146aC > G and miR-196a2T > C were different between the unknown RPL and control groups, these difference were not statistically significant. The results of the present study are similar to the results of previous studies but differ in some respects. This was probably due to the differences in the ethnicity of the study groups. However, more research is necessary to elucidate the positive or negative relationships between these polymorphisms and RPL in women of varied ethnicities.

Coi Statement

All authors declare that they have no financial interest with respect to this study.

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