Neuroanatomical Insights in Adolescents with Endometriosis and Pain

Marco Aurélio Pinho Oliveira, Thiers Soares Raymundo, José Duván López-Jaramillo, Jorge Darío López-Isanoa, Juan Diego Villegas‐Echeverri
In: Endometriosis in Adolescents · 2020 · pp. 227–245 · doi:10.1007/978-3-030-52984-0_10 · W3103294126
book-chapter OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This chapter summarizes the neuroanatomical basis for the modulation of acute to chronic pain, focusing on how endometriosis can lead to central sensitization and chronic pain.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This chapter examines mechanisms of pain from acute to chronic states, focusing on the neuroanatomical and biological processes of nociceptive, inflammatory, and neuropathic pain, with adolescents with endometriosis and pain used as the contextual frame. It summarizes how endometriosis-related injury to the somatosensory nervous system can occur via lesion infiltration or inflammatory mediator release, with nerve growth factor (NGF) from lesions contributing to peripheral sensitization and potentially leading to central sensitization if not addressed promptly. A key limitation is that it is a narrative review/chapter rather than presenting original adolescent data or a systematic empirical analysis with explicit methods. This paper is centrally about endometriosis — it outlines neuroanatomical pathways linking endometriosis-associated NGF/peripheral sensitization to central sensitization in adolescents with pain.

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endometriosis

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