Neuroanatomical Insights in Adolescents with Endometriosis and Pain

Nociceptive, inflammatory, and neuropathic pain are the most clinically important biologic mechanisms of pain. Acute pain and chronic pain are totally different not only in terms of etiology but also in terms of their course, diagnosis, treatment, and prognosis. Acute pain is caused by a specific disease or injury and is self-limiting in the majority of cases. In contrast, chronic pain must be considered as a disease in its own right. Endometriosis is a chronic inflammatory disease and may cause injury to the somatosensory nervous system. Injury occurs by direct infiltration of the lesion or by the production of inflammatory substances near the nerves. Nerve growth factor (NGF) is produced by endometriotic lesions, and it is involved in peripheral sensitization. Adolescents with endometriosis and pain if not treated promptly may develop central sensitization and chronic pain. This chapter summarizes the neuroanatomical basis for the modulation from acute to chronic pain. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

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