{"paper_id":"446c581f-9121-4054-bf1b-cf408bdc726a","body_text":"Abstract\nNociceptive, inflammatory, and neuropathic pain are the most clinically important biologic mechanisms of pain. Acute pain and chronic pain are totally different not only in terms of etiology but also in terms of their course, diagnosis, treatment, and prognosis. Acute pain is caused by a specific disease or injury and is self-limiting in the majority of cases. In contrast, chronic pain must be considered as a disease in its own right. Endometriosis is a chronic inflammatory disease and may cause injury to the somatosensory nervous system. Injury occurs by direct infiltration of the lesion or by the production of inflammatory substances near the nerves. Nerve growth factor (NGF) is produced by endometriotic lesions, and it is involved in peripheral sensitization. Adolescents with endometriosis and pain if not treated promptly may develop central sensitization and chronic pain. 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Obstet Gynecol Clin N Am. 2014;41:397–407.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 2020 Springer Nature Switzerland AG\nAbout this chapter\nCite this chapter\nOliveira, M.A.P., Raymundo, T.S., Lopez-Jaramillo, J.D., Lopez-Isanoa, J.D., Villegas-Echeverri, J.D. (2020). Neuroanatomical Insights in Adolescents with Endometriosis and Pain. In: Nezhat, C.H. (eds) Endometriosis in Adolescents. Springer, Cham. https://doi.org/10.1007/978-3-030-52984-0_10\nDownload citation\nDOI: https://doi.org/10.1007/978-3-030-52984-0_10\nPublished:\nPublisher Name: Springer, Cham\nPrint ISBN: 978-3-030-52983-3\nOnline ISBN: 978-3-030-52984-0\neBook Packages: MedicineMedicine (R0)","source_license":"CC0","license_restricted":false}